{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T18:26:19Z","timestamp":1781029579206,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Guselkumab is a fully human monoclonal antibody that binds selectively to the p19 subunit of interleukin\u201023, which has shown efficacy in patients with previous incomplete response to ustekinumab in the NAVIGATE clinical trial. [Correction added on [28\u201002\u20102023], after first online publication: \u2018humanized monoclonal antibody\u2019 has been changed to 'fully human monoclonal antibody' in the preceding sentence.]<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We conducted a 104\u2010week multicenter retrospective study to assess the effectiveness and safety of guselkumab in patients affected by plaque psoriasis with an inadequate response to ustekinumab in a real\u2010life setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our retrospective study included 233 adults affected by moderate\u2010to\u2010severe plaque psoriasis, enrolled in 14 different Italian centres, and treated with guselkumab after failing therapy with ustekinumab. Patient characteristics and PASI (Psoriasis Area and Severity Index) score at each visit (baseline, weeks 16, 52 and 104) were recorded. The percentages of patients achieving 75%, 90% and 100% (PASI 75, PASI 90 and PASI 100) improvement in PASI, compared with baseline, were registered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At week 52, PASI 75 was reached by 89.88% of patients, PASI 90 by 71.43%, PASI 100 by 58.83% and absolute PASI \u22642 by 90.48%. At week 104, similar effectiveness results were observed. Compared to the NAVIGATE trial, we observed higher rates of PASI 75\/90\/100. Patients with the involvement of difficult\u2010to\u2010treat areas were significantly less likely to achieve PASI90 and PASI100 at week 16. Obese patients had significantly lower rates of PASI75 and PASI \u22642 at week 52. At week 104, comparable responses were observed among all patients' subgroups, regardless of BMI status, involvement of difficult\u2010to\u2010treat areas, presence of cardiometabolic comorbidities and concomitant psoriatic arthritis. No significant safety findings were reported throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that the efficacy of guselkumab in patients with inadequate response to ustekinumab for plaque psoriasis in \u2018real\u2010life\u2019 clinical practice is comparable with NAVIGATE study with higher percentages of patients achieving PASI90 and PASI100 at weeks 16, 52 and 104.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18913","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T08:18:10Z","timestamp":1674634690000},"page":"1017-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Real\u2010life effectiveness and safety of guselkumab in patients with psoriasis who have an inadequate response to ustekinumab: A\u00a0104\u2010week multicenter retrospective study \u2013 <scp>IL PSO<\/scp> (<scp>ITALIAN LANDSCAPE PSORIASIS<\/scp>)"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6051-1676","authenticated-orcid":false,"given":"Luigi","family":"Gargiulo","sequence":"first","affiliation":[{"name":"Dermatology Unit IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7876-4866","authenticated-orcid":false,"given":"Luciano","family":"Ibba","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piergiorgio","family":"Malagoli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dermatology Unit Azienda Ospedaliera San Donato Milanese  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Giuseppa","family":"Angileri","sequence":"additional","affiliation":[{"name":"UOC Dermatologia ARNAS Civico Di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bardazzi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Specialistic, Diagnostic and Experimental Medicine S. Orsola\u2010Malpighi Hospital, University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6295-3574","authenticated-orcid":false,"given":"Nicoletta","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Dermatology Unit \"Daniele Innocenzi\", Department of Medical\u2010Surgical Sciences and Bio\u2010Technologies Sapienza University of Rome, Fiorini Hospital  Terracina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Burlando","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences (DISSAL) IRCCS San Martino University Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo G.","family":"Carrera","sequence":"additional","affiliation":[{"name":"Fondazione C\u00e0 Granda IRCCS Maggiore Policlinico Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6739-0387","authenticated-orcid":false,"given":"Andrea","family":"Chiricozzi","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Dapavo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-1999","authenticated-orcid":false,"given":"Valentina","family":"Dini","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Clinical and Experimental Medicine Ospedale Santa Chiara  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Fabbrocini","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Maria","family":"Gaiani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dermatology Unit Azienda Ospedaliera San Donato Milanese  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-5175","authenticated-orcid":false,"given":"Marco","family":"Galluzzo","sequence":"additional","affiliation":[{"name":"Dermatology, Department of Systems Medicine University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Giofr\u00e9","sequence":"additional","affiliation":[{"name":"U.O.C. 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