{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:33:24Z","timestamp":1790386404208,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although ocular adverse events are frequent in AD patients treated with dupilumab, their characterization remains limited due to a lack of prospective studies with a systematic ophthalmological examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the incidence, characteristics and risk factors of dupilumab\u2010induced ocular adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, multicenter, and real\u2010life study in adult AD patients treated with dupilumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 27 out of 181 patients (14.9%) had conjunctivitis. At week 16 (W16), 25 out of 27 had improved their conjunctivitis and 2 remained stable and 34 out of 181 patients (18.7%) had dupilumab\u2010induced blepharoconjunctivitis: either de novo (<jats:italic>n<\/jats:italic>\u00a0=\u00a032) or worsening of underlying blepharoconjunctivitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). Most events (27\/34; 79.4%) were moderate. A multivariate analysis showed that head and neck AD (OR\u00a0=\u00a07.254; 95%CI [1.938\u201330.07]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), erythroderma (OR\u00a0=\u00a05.635; 95%CI [1.635\u201321.50]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) and the presence of dry eye syndrome at baseline (OR\u00a0=\u00a03.51; 95%CI [3.158\u201313.90]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.031) were independent factors associated with dupilumab\u2010induced blepharoconjunctivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Our follow\u2010up period was 16\u2009weeks and some late\u2010onset time effects may still occur.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that most dupilumab\u2010induced blepharoconjunctivitis cases are de novo. AD severity and conjunctivitis at baseline were not found to be associated risk factors in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18932","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T02:33:22Z","timestamp":1675391602000},"page":"1056-1063","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Multicenter prospective observational study of dupilumab\u2010induced ocular events in atopic dermatitis patients"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1057-1010","authenticated-orcid":false,"given":"Ingrid","family":"Costedoat","sequence":"first","affiliation":[{"name":"CHU de Bordeaux, National Reference Center for Rare Skin Diseases, CNRS UMR5164, ImmunoConCept Univ. 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Robert\u2010Debr\u00e9  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuelle","family":"Viguier","sequence":"additional","affiliation":[{"name":"Department of Dermatology\u2010Venerology CHU Robert\u2010Debr\u00e9  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Cordelette","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology CHU Robert\u2010Debr\u00e9  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Denoyer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology CHU Robert\u2010Debr\u00e9  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Ferrier\u00a0le\u00a0Bou\u00ebdec","sequence":"additional","affiliation":[{"name":"Department of Dermatology\u2010Venerology and Ophthalmology Centre Hospitalier Universitaire Clermont\u2010Ferrand  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