{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:34:03Z","timestamp":1781537643387,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"S5","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Moderate to severe AD can be successfully managed by systemic treatments. Current guidelines also recommend emollients or emollients \u2018plus\u2019 and eudermic cleansers for all AD patients to improve the skin barrier and provide anti\u2010irritant and anti\u2010pruritic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the efficacy of skin care (in addition to systemic treatment) with an Emollient \u2018plus\u2019 balm designed to improve the skin barrier and skin microbiome plus a corresponding syndet compared to usual commercial emollients and cleansers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomized controlled multicenter study, patients with moderate to severe AD (Severity scoring of atopic dermatitis [SCORAD] score\u2009\u2265\u200940) receiving systemic treatment (cyclosporin A, dupilumab or a Janus kinase inhibitor) were randomized 1:1 to apply twice daily for 10\u2009weeks Emollient \u2018plus\u2019 after pre\u2010cleaning with the syndet (Emollient \u2018plus\u2019 group) or to continue with their usual emollient and cleanser (Control group). Assessments included SCORAD, pruritus on a Visual Analog Scale, Dermatology quality of life questionnaire (DLQI), efficacy and tolerance questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Included were 57 patients with mean age of 38\u2009years (range 19\u201370\u2009years). The mean amount of emollient used after 10\u2009weeks was 447.3\u00a0g (range 29\u20131099\u2009g) and 613.2\u00a0g (range 97\u20132565\u2009g) for the Emollient \u2018plus\u2019 versus the Control, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u20090.0277). After 10\u2009weeks, subjects in the Emollient \u2018plus\u2019 had a significantly greater reduction in current pruritus (<jats:italic>p<\/jats:italic>\u00a0=\u20090.0277) and a greater reduction in some DLQI items compared to the Control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with moderate to severe AD receiving systemic treatment, the Emollient \u2018plus\u2019 regimen significantly improved pruritus and quality of life items compared to the control, while using 23% less product over a 10\u2010week period. These results stress the importance of daily use of emollients, especially emollients \u2018plus\u2019 to improve signs, symptoms and quality of life in patients with AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.18949","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T08:02:04Z","timestamp":1682323324000},"page":"18-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of different skin care regimens in patients with moderate to severe atopic dermatitis receiving systemic treatment: A randomized controlled trial"],"prefix":"10.1111","volume":"37","author":[{"given":"Nina","family":"Magnolo","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-8086","authenticated-orcid":false,"given":"Thomas","family":"Jaenicke","sequence":"additional","affiliation":[{"name":"IUF \u2013 Leibniz Research Institute for Environmental Medicine  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Tsianakas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fachklinik Bad Bentheim  Bad Bentheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Czech","sequence":"additional","affiliation":[{"name":"Dermatology and Allergology Clinic University of Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8513-550X","authenticated-orcid":false,"given":"Diamant","family":"Tha\u00e7i","sequence":"additional","affiliation":[{"name":"Institute and Comprehensive Center Inflammation Medicine University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-1502","authenticated-orcid":false,"given":"Andreas","family":"Pinter","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology, Venereology, and Allergology University Hospital of Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-4261","authenticated-orcid":false,"given":"Delphine","family":"Kerob","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-3183","authenticated-orcid":false,"given":"Samir","family":"Salah","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1397-1626","authenticated-orcid":false,"given":"Thomas A.","family":"Luger","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.530"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.12.020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13401"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00266-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2018.10.3.207"},{"key":"e_1_2_11_7_1","first-page":"21","article-title":"Atopic dermatitis: an expanding therapeutic 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