{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:00Z","timestamp":1772160660955,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent real\u2010world studies have reported significant improvements in the survival of malignant melanoma in the past few years, mainly as a result of modern therapies. However, long\u2010term survival data from Central Eastern European countries such as Hungary are currently lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This nationwide, retrospective study examined melanoma survival in Hungary between 2011\u20132019 using the databases of the National Health Insurance Fund (NHIF) and Central Statistical Office (CSO) of Hungary. Crude overall survival and age\u2010standardized 5\u2010year net survival as well as the association between age, sex and survival were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between 2011 and 2019, 22,948 newly diagnosed malignant melanoma cases were recorded in the NHIF database (47.89% male, mean age: 60.75\u2009years (SD: \u00b116.39)). Five\u2010year overall survival was 75.40% (women: 80.78%; men: 69.52%). Patients diagnosed between 2017\u20132019 had a 20% lower risk of mortality compared to patients diagnosed between 2011\u20132012 (HR 0.80, 95% CI 0.73\u20130.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Age\u2010standardized 5\u2010year net survival rates in 2011\u20132014 and 2015\u20132019 were 90.6% and 95.8%, respectively (women: 93.1% and 98.4%, men: 87.8% and 92.7%, respectively). The highest age\u2010standardized 5\u2010year net survival rates were found in the 0\u201339 age cohort (94.6% in the 2015\u20132019 period).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hungary has similar melanoma survival rates to Western European countries. Based on net survival, the risk of dying of melanoma within 5\u2009years was cut by more than half (55%) during the study period, which coincides with the successful implementation of awareness campaigns and the wide availability of modern therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.18960","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T03:10:28Z","timestamp":1676344228000},"page":"932-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Significant improvement in melanoma survival over the last decade: A Hungarian nationwide study between 2011 and 2019"],"prefix":"10.1111","volume":"37","author":[{"given":"Gabriella","family":"Liszkay","sequence":"first","affiliation":[{"name":"Department of Molecular Immunology and Toxicology and the National Tumorbiology Laboratory National Institute of Oncology  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Benedek","sequence":"additional","affiliation":[{"name":"MSD Pharma Hungary Ltd.  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Polg\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology and Toxicology and the National Tumorbiology Laboratory National Institute of Oncology  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University of Szeged  Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Holl\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2877-4740","authenticated-orcid":false,"given":"Gabriella","family":"Emri","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Csejtei","sequence":"additional","affiliation":[{"name":"Department of Oncoradiology Markusovszky University Teaching Hospital  Szombathely Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Kenessey","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology and Toxicology and the National Tumorbiology Laboratory National Institute of Oncology  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Pol\u00e1nyi","sequence":"additional","affiliation":[{"name":"MSD Pharma Hungary Ltd.  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-7165","authenticated-orcid":false,"given":"Kata","family":"Knollmajer","sequence":"additional","affiliation":[{"name":"MSD Pharma Hungary Ltd.  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1t\u00e9","family":"V\u00e1rnai","sequence":"additional","affiliation":[{"name":"MSD Pharma Hungary Ltd.  Budapest Hungary"},{"name":"Center for Health Technology Assessment Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Vok\u00f3","sequence":"additional","affiliation":[{"name":"Center for Health Technology Assessment Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Nagy","sequence":"additional","affiliation":[{"name":"Center for Health Technology Assessment Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Rokszin","sequence":"additional","affiliation":[{"name":"RxTarget Ltd.  Szolnok Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibolya","family":"F\u00e1bi\u00e1n","sequence":"additional","affiliation":[{"name":"RxTarget Ltd.  Szolnok Hungary"},{"name":"University of Veterinary Medicine  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Barcza","sequence":"additional","affiliation":[{"name":"Syntesia Medical Communications Ltd.  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-8846","authenticated-orcid":false,"given":"Rolland","family":"Gyulai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Oncodermatology, Faculty of Medicine University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Kiss","sequence":"additional","affiliation":[{"name":"MSD Pharma Hungary Ltd.  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2006.05.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052166"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12236"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.01.035"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.612459"},{"issue":"21","key":"e_1_2_10_8_1","first-page":"591","article-title":"Centers for Disease Control and Prevention (CDC). 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