{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:31Z","timestamp":1787015551784,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Adverse pregnancy outcomes (APO) occur in 35% of patients with pemphigoid gestationis (PG). No biological predictor of APO has been established yet.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To assess a potential relationship between the occurrence of APO and the serum value of anti\u2010BP180 antibodies at the time of PG diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Multicentre retrospective study conducted from January 2009 to December 2019 in 35 secondary and tertiary care centres. Inclusion criteria: (i) diagnosis of PG according to clinical, histological and immunological criteria, (ii) ELISA measurement of anti\u2010BP180 IgG antibodies determined at the time of PG diagnosis with the same commercial kit and (iii) obstetrical data available.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 95 patients with PG included, 42 had one or more APO, which mainly corresponded to preterm birth (\n n<\/jats:italic>\n \u00a0=\u200926), intrauterine growth restriction (IUGR) (\n n<\/jats:italic>\n \u00a0=\u200918) and small weight for gestational age at birth (\n n<\/jats:italic>\n \u00a0=\u200916). From a ROC curve, we identified a threshold of 150\u2009IU ELISA value as the most discriminating to differentiate between patients with or without IUGR, with 78% sensitivity, 55% specificity, 30% positive and 91% negative predictive value. The threshold >150\u2009IU was confirmed using a cross\u2010validation based on bootstrap resampling, which showed that the median threshold was 159\u2009IU. Upon adjusting for oral corticosteroid intake and main clinical predictors of APO, an ELISA value of >150\u2009IU was associated with the occurrence of IUGR (OR\u00a0=\u00a05.11; 95% CI: 1.48\u201322.30;\n p<\/jats:italic>\n \u00a0=\u00a00.016) but not with any other APO. The combination of blisters and ELISA values higher than 150\u2009IU led to a 2.4\u2010fold higher risk of all\u2010cause APO (OR: 10.90; 95% CI: 2.33\u201382.3) relative to patients with blisters but lower values of anti\u2010BP180 antibodies (OR of 4.54; 95% CI 0.92\u201334.2).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These findings suggest that anti\u2010BP180 antibody ELISA value in combination with clinical markers is helpful in managing the risk of APO, in particular IUGR, in patients with PG.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.18973","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T13:38:26Z","timestamp":1676727506000},"page":"1207-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Anti\u2010BP180 IgG<\/scp>\n antibody\n ELISA<\/scp>\n values correlate with adverse pregnancy outcomes in pemphigoid gestationis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1679-8005","authenticated-orcid":false,"given":"Nad\u00e8ge","family":"Cordel","sequence":"first","affiliation":[{"name":"Department of Dermatology and Clinical Immunology Guadeloupe University Hospital Pointe\u2010\u00e0\u2010Pitre Guadeloupe"},{"name":"Univ Rouen Normandie FOCIS Center of Excellence PAn'THER Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Flament","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Jouen","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie FOCIS Center of Excellence PAn'THER Rouen France"},{"name":"Department of Immunology and biotherapies Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vannina","family":"Seta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cochin Hospital AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Tancr\u00e8de\u2010Bohin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Saint Louis Hospital AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Picard","family":"Dahan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bichat Hospital AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-6542","authenticated-orcid":false,"given":"Maria\u2010Polina","family":"Konstantinou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-1922","authenticated-orcid":false,"given":"Olivier","family":"Dereure","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint\u2010Eloi University Hospital Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Qu\u00e9reux","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantes University Hospital Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Prost","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Avicenne Hospital AP\u2010HP Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bedane","sequence":"additional","affiliation":[{"name":"Department of Dermatology Limoges University Hospital Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Debarbieux","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4tel Dieu Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Lacour","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Nice Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dompmartin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Caen University Hospital Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wierzbicka\u2010Hainaut","sequence":"additional","affiliation":[{"name":"Department of Dermatology Poitiers University Hospital Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle Bourgault","family":"Villada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ambroise Par\u00e9 Hospital, AP\u2010HP Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-7096","authenticated-orcid":false,"given":"Saskia Ingen Housz","family":"Oro","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henri Mondor Hospital AP\u2010HP and Univ Paris Est Cr\u00e9teil, EpidermE Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Vabres","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dijon University Hospital Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Aleth","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Dermatology La Timone University Hospital APHM Marseille 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Dermatology, Monod General Hospital Le Havre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Emile Muller Hospital Mulhouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henri\u2010Duffaut Hospital Avignon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"D'Incan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Clermont\u2010Ferrand University Hospital Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Abasq","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brest University Hospital Brest 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lombart","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amiens University Hospital Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Est\u00e8ve","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Orl\u00e9ans Regional Hospital Orl\u00e9ans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-878X","authenticated-orcid":false,"given":"Laurent","family":"Machet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tours University Hospital Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Del\u00a0Giudice","sequence":"additional","affiliation":[{"name":"Infectiology\u2010Dermatology Unit, Intercommunal Hospital of Fr\u00e9jus Saint Rapha\u00ebl Fr\u00e9jus 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VabresP.Pronostic de la pemphigo\u00efde gestationnelle chez le foetus et le nouveau\u2010n\u00e9: revue syst\u00e9matique de la litt\u00e9rature.2019Published online October 24."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.004"}],"container-title":["Journal of the European Academy of Dermatology and 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