{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:20:19Z","timestamp":1787163619484,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22he0422021j0001"],"award-info":[{"award-number":["JP22he0422021j0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008040","name":"Kao Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The molecular pathogenesis of atopic dermatitis (AD), presenting skin barrier dysfunction and abnormal inflammations around 1\u20132\u2009months, is unreported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to examine the molecular pathogenesis of very early\u2010onset AD by skin surface lipid\u2010RNA (SSL\u2010RNA) using a non\u2010invasive technology in infants aged 1 and 2\u00a0months from a prospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected sebum by oil\u2010blotting film of infants aged 1 and 2\u00a0months and analysed RNAs in their sebum. We diagnosed AD according to the United Kingdom Working Party's criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Infants with AD aged 1\u2009month showed lower expression of genes related to various lipid metabolism and synthesis, antimicrobial peptides, tight junctions, desmosomes and keratinization. They also had higher expression of several genes involved in Th2\u2010, Th17\u2010 and Th22\u2010type immune responses and lower expression of negative regulators of inflammation. In addition, gene expressions related to innate immunity were higher in AD infants. Infants aged 1\u2009month with neonatal acne and diagnosed with AD aged 2\u2009months already had gene expression patterns similar to AD aged 1\u2009month in terms of redox, lipid synthesis, metabolism and barrier\u2010related gene expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We identified molecular changes in barrier function and inflammatory markers that characterize the pathophysiology of AD in infants aged 1\u2009month. We also revealed that neonatal acne at 1\u2009month could predict the subsequent development of AD by sebum transcriptome data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.19017","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T11:04:45Z","timestamp":1678446285000},"page":"1385-1395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["<scp>mRNAs<\/scp>\n                    in skin surface lipids unveiled atopic dermatitis at 1\u2009month"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-9620","authenticated-orcid":false,"given":"Kiwako","family":"Yamamoto\u2010Hanada","sequence":"first","affiliation":[{"name":"Allergy Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-7034","authenticated-orcid":false,"given":"Mayako","family":"Saito\u2010Abe","sequence":"additional","affiliation":[{"name":"Allergy Center National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-5400","authenticated-orcid":false,"given":"Kyoko","family":"Shima","sequence":"additional","affiliation":[{"name":"Biological Science Research, Kao Corporation  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-7868","authenticated-orcid":false,"given":"Satoko","family":"Fukagawa","sequence":"additional","affiliation":[{"name":"Biological Science Research, Kao Corporation  Tochigi 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