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Treatment of vitiligo should control the exaggerated immune response to arrest the progress of active disease, and then promote melanocytes to repigmentation. Wnt\/\u03b2\u2010catenin signalling pathway has been of recent interest in vitiligo. Wnt\/\u03b2\u2010catenin signalling pathway is downregulated in vitiligo. Upregulation of Wnt\/\u03b2\u2010catenin signalling possibly control vitiligo autoimmune response by protecting melanocyte from OS damage, inhibiting CD8<jats:sup>+<\/jats:sup> T cell effector cell differentiation and enhancing Treg. Wnt\/\u03b2\u2010catenin signalling plays a critical role in the melanocyte regeneration by driving the differentiation of melanocyte stem cells (McSCs) into melanocytes. Promoting Wnt\/\u03b2\u2010catenin signalling can not only arrest the progress of active disease of vitiligo but also promote repigmentation. Some of the main effective therapies for vitiligo are likely to work by activating Wnt\/\u03b2\u2010catenin signalling. 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