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This transcriptomic signature in psoriasis versus controls was evaluated in two CVD cohorts: Women referred for cardiac catheterization with (<jats:italic>n<\/jats:italic>\u00a0=\u00a076) versus without (<jats:italic>n<\/jats:italic>\u00a0=\u00a097) myocardial infarction (MI), and patients with peripheral artery disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a0106) followed over 2.5\u2009years for major adverse CV or limb events (MACLE). The association between genes differentially expressed in psoriasis and prevalent and incident CV events was assed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In psoriasis, median age was 44 (IQR; 34\u201351) years, 49% male and ACC\/AHA ASCVD Risk Score of 1.0% (0.6\u20133.4) with no significant difference versus controls. The median psoriasis area and severity index score (PASI) was 4.0 (IQR 2.9\u20138.2) with 36% on biologic therapy. Overall, 247 whole blood genes were upregulated and 228 downregulated in psoriasis versus controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and 1302 genes positively and 1244 genes negatively correlated with PASI (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Seventy\u2010three genes overlapped between psoriasis prevalence and PASI with key regulators identified as IL\u20106, IL\u20101\u03b2 and interferon gamma. In the CVD cohorts, 50 of 73 genes (68%) identified in psoriasis associated with prevalent MI, and 29 (40%) with incident MACLE. Key regulator transcripts identified in psoriasis and CVD cohorts included <jats:italic>SOCS3<\/jats:italic>, <jats:italic>BCL3<\/jats:italic>, <jats:italic>OSM<\/jats:italic>, <jats:italic>PIM2<\/jats:italic>, <jats:italic>PIM3<\/jats:italic> and <jats:italic>STAT5A<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A whole blood transcriptomic signature of psoriasis diagnosis and severity associated with prevalent MI and incident MACLE. These data have implications for better understanding the link between psoriasis, systemic inflammation and CVD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19049","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T06:49:36Z","timestamp":1678949376000},"page":"1361-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["An inflammatory transcriptomic signature in psoriasis associates with future cardiovascular events"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-3755","authenticated-orcid":false,"given":"Michael S.","family":"Garshick","sequence":"first","affiliation":[{"name":"Department of Medicine, Center for the Prevention of Cardiovascular Disease New\u00a0York University School of Medicine  New York City New York USA"},{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center New York University School of Medicine  New York City New York USA"},{"name":"Ronald O. Perelman Department of Dermatology New York University School of Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa J.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center New York University School of Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MacIntosh G.","family":"Cornwell","sequence":"additional","affiliation":[{"name":"Division of Precision Medicine New York University School of Medicine  New York City New York USA"},{"name":"Institute for Systems Genetics New York University School of Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamelia","family":"Drenkova","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center New York University School of Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Garelik","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman Department of Dermatology New York University School of Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany N.","family":"Weber","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Schlamp","sequence":"additional","affiliation":[{"name":"Leon H. 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