{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:30:45Z","timestamp":1771997445763,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melanoma guidelines recommend surgical excision with 10\u2009mm margins for T1 melanomas (invasive melanomas with Breslow thickness \u22641\u2009mm), including those in radial growth phase, which are without metastatic potential; however, such margins may be problematic on head\u2010and\u2010neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We compared outcomes of wide (10\u2009mm margins) versus narrow (5\u2009mm margins) excisions in patients with radial growth phase T1 melanoma on head\u2010and\u2010neck including face.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively examined 610 consecutive patients excised with wide versus narrow margins, from 2001 to 2018, at six European centres. In all cases, radial growth phase, and clear margins with 5 or 10\u2009mm of clearance, were ascertained histologically. Multivariable models investigated associations of margins and other factors with overall survival and local recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and sixteen (51.8%) patients received wide excision, 219 (69.3%) with primary wound closure, 97 (30.7%) with reconstruction; 294 (48.2%) patients received narrow excision, 264 (89.8%) with primary wound closure, 30 (10.2%) with reconstruction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Median follow\u2010ups were 88\u2009months (wide) and 187\u2009months (narrow) (inter\u2010quartile ranges 43\u2013133 and 79\u2013206, respectively). Ten\u2010year overall survival (95% confidence interval) was 96.7% (94.2%\u201399.3%) in wide and 98.2% (96.4%\u2013100%) in narrow patients. Ten\u2010year local recurrence incidence was 6.4% (4.1%\u201310.1%) in wide and 7.8% (5.3%\u201311.6%) in narrow groups. Lentigo maligna melanoma subtype appeared associated with increased risk of local recurrence in narrow versus wide patients (15.0% vs. 7.5%;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.190).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Narrower excision margins for T1 radial growth phase melanoma are not associated with worse overall survival (hazard ratio 0.97,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.996) or increased local recurrence (subdistribution hazard ratio: 0.87;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.751) compared to wider margins, and may be safely applied to such lesions, although caution may be required in the presence of lentigo maligna melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19051","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T07:05:21Z","timestamp":1678950321000},"page":"1318-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Similar local recurrence and survival in patients with<scp>T1<\/scp>radial growth phase melanoma on head and neck treated with 5 or 10\u2009mm margins: A retrospective study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-5373","authenticated-orcid":false,"given":"Andrea","family":"Maurichi","sequence":"first","affiliation":[{"name":"Melanoma Surgical Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Barretta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science Fondazione IRCCS 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Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Leva","sequence":"additional","affiliation":[{"name":"Melanoma Surgical Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Harwood","sequence":"additional","affiliation":[{"name":"Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffanie\u2010Marie","family":"Borg","sequence":"additional","affiliation":[{"name":"Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Shimonovitz\u2010Moore","sequence":"additional","affiliation":[{"name":"Melanoma Surgical Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"},{"name":"Peritoneal Surface Malignancy and Melanoma Unit, Department of Surgery A Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Spadola","sequence":"additional","affiliation":[{"name":"Melanoma Surgical Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Tolomio","sequence":"additional","affiliation":[{"name":"Melanoma Surgical Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Melanoma Surgical Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan 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