{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:19:01Z","timestamp":1773832741148,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anti\u2010drug antibodies (ADA) are formed in patients treated with adalimumab (ADL). This might increase clearance of ADL, potentially causing a (secondary) non\u2010response. Combination therapy of ADL and methotrexate (MTX) reduces ADA levels and has a clinical benefit in rheumatologic diseases. In psoriasis however, the long\u2010term effectiveness and safety have not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the three\u2010year follow\u2010up data of ADL combined with MTX compared to ADL monotherapy in ADL\u2010naive patients with moderate to severe plaque type psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicentre RCT in the Netherlands and Belgium. Randomization was performed by a centralized online randomization service. Patients were seen every 12\u2009weeks until week 145. Outcome assessors were blinded. We collected data on drug survival, effectiveness, safety, pharmacokinetics and immunogenicity of patients that started ADL combined with MTX compared to ADL monotherapy. We present descriptive analysis and patients were analysed according to the group initially randomized to. Patients becoming non\u2010adherent to the biologic were excluded from analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients were included and 37 patients (ADL group <jats:italic>n<\/jats:italic>\u2009=\u200917, ADL\u2009+\u2009MTX group <jats:italic>n<\/jats:italic>\u2009=\u200920) continued in the follow\u2010up study after 1\u2009year. After 109\u2009weeks and 145\u2009weeks, there was a trend towards longer drug survival in the ADL\u2009+\u2009MTX group compared to the ADL group (week 109: 54.8% vs. 41.4%; <jats:italic>p<\/jats:italic>\u2009=\u20090.326, week 145: 51.6% vs. 41.4%; <jats:italic>p<\/jats:italic>\u2009=\u20090.464). At week 145, 7\/13 patients were treated with MTX. In the ADL group, 4\/12 patients that completed the study developed ADA, and 3\/13 in the ADL\u2009+\u2009MTX group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this small study, there was no significant difference in ADL overall drug survival when it was initially combined with MTX, compared to ADL alone. Discontinuation due to adverse events was common in the combination group. To secure accessible healthcare, combination treatment of ADL and MTX can be considered in individual patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19089","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T14:32:53Z","timestamp":1680618773000},"page":"1815-1824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adalimumab combined with methotrexate versus adalimumab monotherapy in psoriasis: Three\u2010year follow\u2010up data of a single\u2010blind randomized controlled trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6664-2490","authenticated-orcid":false,"given":"Astrid M.","family":"van Huizen","sequence":"first","affiliation":[{"name":"Department of Dermatology Amsterdam UMC, Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-6116","authenticated-orcid":false,"given":"Gayle E.","family":"van der Kraaij","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amsterdam UMC, Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7074-7060","authenticated-orcid":false,"given":"Celine I.","family":"Busard","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amsterdam UMC, Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-9358","authenticated-orcid":false,"given":"Wouter","family":"Ouwerkerk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Data Science, Biostatistics and Bioinformatics, Amsterdam UMC Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"},{"name":"National Heart Centre Singapore  Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3642-2673","authenticated-orcid":false,"given":"Juul M. P. A.","family":"van den Reek","sequence":"additional","affiliation":[{"name":"Radboud UMC, Radboud University Department of Dermatology  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6522-7220","authenticated-orcid":false,"given":"Stef P.","family":"Menting","sequence":"additional","affiliation":[{"name":"Department of Dermatology OLVG  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8158-660X","authenticated-orcid":false,"given":"Errol P.","family":"Prens","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus MC  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-1312","authenticated-orcid":false,"given":"Theo","family":"Rispens","sequence":"additional","affiliation":[{"name":"Sanquin Research and Landsteiner Laboratory, Department of Blood Cell Research, Academic Medical Centre University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7570-473X","authenticated-orcid":false,"given":"Annick","family":"de Vries","sequence":"additional","affiliation":[{"name":"Sanquin Pharma&amp;Biotech Services, Sanquin  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3872-5704","authenticated-orcid":false,"given":"Elke M. G. J.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Radboud UMC, Radboud University Department of Dermatology  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-9310","authenticated-orcid":false,"given":"Jo","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-7899","authenticated-orcid":false,"given":"Martijn B. A.","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus MC  Rotterdam The Netherlands"},{"name":"Centre for Human Drug Research  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-2863","authenticated-orcid":false,"given":"Phyllis I.","family":"Spuls","sequence":"additional","affiliation":[{"name":"Department of Dermatology Amsterdam UMC, Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000494"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.380"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.295"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-017-0231-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.8347"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13112"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201544"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202347"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210715"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22510"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22379"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217372"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1610-0387.2012.07976.x","article-title":"Combination of adalimumab with traditional systemic antipsoriatic drugs \u2013 a report of 39 cases","volume":"1011","author":"Philipp S","year":"2012","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.751483"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20885"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.01.033"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.07.028"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1777-y"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1080-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.12.040"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2043546"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2010.09.005"},{"key":"e_1_2_10_25_1","first-page":"170","article-title":"Update richtlijn psoriasis 2017 [Dutch]","volume":"274","author":"Van Der Kraaij GE","year":"2017","journal-title":"Nederlands Tijdschrift voor Dermatologie en Venereologie"},{"key":"e_1_2_10_26_1","unstructured":"MedDRA.MedDRA website.2021."},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16102"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz294"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1636963"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.6040"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2900"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13087"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.19089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:07:39Z","timestamp":1692950859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.19089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/jdv.19089"],"URL":"https:\/\/doi.org\/10.1111\/jdv.19089","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]},"assertion":[{"value":"2022-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}