{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:06Z","timestamp":1787169666246,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T00:00:00Z","timestamp":1683331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004690","name":"Minist\u00e8re de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lentigo maligna (LM) is a melanocytic proliferation occurring on photo\u2010exposed skin that may progress to LM melanoma. Surgery is recommended as first\u2010line treatment. Excision margins of 5\u201310\u2009mm remain, without international consensus. Several studies have shown that imiquimod, an immunomodulator, induces LM regression. This study investigated the effect of imiquimod versus placebo in neoadjuvant settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We performed a prospective, randomized, multicentre, phase III clinical study. Patients were randomly assigned in 1:1 ratio to receive imiquimod or placebo for 4\u2009weeks, followed by LM excision 4\u2009weeks after the last application of imiquimod or placebo. The primary endpoint was extra\u2010lesional excision, with a 5\u2009mm margin from the residual pigmentation after imiquimod or vehicle. Secondary endpoints included the gain on the surface removed between the two groups; number of revision surgeries to obtain extra\u2010lesional excisions; relapse\u2010free time; and number of complete remissions after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 283 patients participated in this study; 247 patients, 121 patients in the placebo group and 126 in the imiquimod group, accounted for the modified ITT population. The first extralesional extirpation was performed in 116 (92%) imiquimod patients and in 102 (84%) placebo patients; the difference was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0743). Regarding the surface of LM, imiquimod reduced the LM surface (4.6\u20133.1\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      ) significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) more compared to the placebo (3.9\u20134.1\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Imiquimod reduces the lentigo maligna surface after 1\u2009month of treatment, without a higher risk of intralesional excision and with a positive aesthetic outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.19141","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T02:37:15Z","timestamp":1682649435000},"page":"1785-1791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of imiquimod in the management of lentigo maligna"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4288-1101","authenticated-orcid":false,"given":"Marie","family":"Daude","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, INSERM, CNRS, CHU Nantes, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302\/EMR6001  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Dinulescu","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Rennes  Rennes 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