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Environmental stress exacerbates and triggers inflammatory skin diseases through modifying the cellular components of the immune system supporting the importance of CRH\u2010POMC system in the pathogenesis of psoriasis. The aim of this study was to analyse the association of <jats:italic>CRH\u2010POMC<\/jats:italic> polymorphisms with psoriasis and evaluate transcript expression of lesional psoriatic and normal skin in RNA\u2010seq data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples of 104 patients with psoriasis and 174 healthy controls were genotyped for 42 single nucleotide polymorphisms (SNPs) of <jats:italic>CRH\u2010POMC<\/jats:italic> using Applied Biosystems SNPlex\u2122 method. The transcript quantification was performed using Salmon software v1.3.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study demonstrated the associations between melanocortin 1 receptor (<jats:italic>MC1R<\/jats:italic>) polymorphisms rs2228479, rs3212369, dopachrome tautomerase (<jats:italic>DCT<\/jats:italic>) polymorphisms rs7987802, rs2031526, rs9524501 and psoriasis in the Tatar population. Very strong association was evident for the SNP rs7987802 in the <jats:italic>DCT<\/jats:italic> gene (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u2009=\u20095.95\u0435\u2010006) in psoriasis patients. Additionally, the haplotype analysis provided AT <jats:italic>DCT<\/jats:italic> (rs7992630 and rs7987802) and AGA <jats:italic>MC1R<\/jats:italic> (rs3212358, 2228479 and 885479) haplotypes significantly associated (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u2009\u02c2\u20090.05) with psoriasis in the Tatar population, supporting the involvement of <jats:italic>DCT<\/jats:italic> and <jats:italic>MC1R<\/jats:italic> to the psoriasis susceptibility. Moreover, MC1R\u2010203 and DCT\u2010201 expression levels were decreased in psoriasis lesional skin compared with healthy control skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is the first to identify genetic variants of the <jats:italic>MC1R<\/jats:italic> and <jats:italic>DCT<\/jats:italic> genes significantly associated with psoriasis in Tatar population. Our results support potential roles of <jats:italic>CRH\u2010POMC<\/jats:italic> system genes and <jats:italic>DCT<\/jats:italic> in the pathogenesis of psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19257","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T17:18:55Z","timestamp":1686849535000},"page":"2028-2040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Polymorphisms in corticotrophin\u2010releasing hormone\u2013proopiomalanocortin (<scp>CRH<\/scp>\u2013<scp>POMC<\/scp>) system genes: Neuroimmune contributions to psoriasis disease"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8773-0932","authenticated-orcid":false,"given":"Elvira","family":"Galimova","sequence":"first","affiliation":[{"name":"Department of Physiology University of Tartu  Tartu 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