{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:59:05Z","timestamp":1784779145992,"version":"3.55.0"},"reference-count":78,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (HS) is a chronic, systemic, inflammatory skin condition with elusive pathogenesis that affects therapeutic intervention directly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize epigenetic variations in cytokines genes contributing to HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Epigenome\u2010wide DNA methylation profiling with the Illumina Epic array was performed on blood DNA samples from 24 HS patients and 24 age\u2010 and sex\u2010matched controls to explore DNA methylation changes in cytokine genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 170 cytokine genes including 27 hypermethylated CpG sites and 143 genes with hypomethylated sites respectively. Hypermethylated genes, including<jats:italic>LIF<\/jats:italic>,<jats:italic>HLA\u2010DRB1<\/jats:italic>,<jats:italic>HLA\u2010G<\/jats:italic>,<jats:italic>MTOR<\/jats:italic>,<jats:italic>FADD<\/jats:italic>,<jats:italic>TGFB3<\/jats:italic>,<jats:italic>MALAT1<\/jats:italic>and<jats:italic>CCL28<\/jats:italic>; hypomethylated genes, including<jats:italic>NCSTN<\/jats:italic>,<jats:italic>SMAD3<\/jats:italic>,<jats:italic>IGF1R<\/jats:italic>,<jats:italic>IL1F9<\/jats:italic>,<jats:italic>NOD2<\/jats:italic>,<jats:italic>NOD1<\/jats:italic>,<jats:italic>YY1<\/jats:italic>,<jats:italic>DLL1<\/jats:italic>and<jats:italic>BCL2<\/jats:italic>may contribute to the pathogenesis of HS. These genes were enriched in the 117 different pathways (FDR<jats:italic>p<\/jats:italic>\u2010values\u2009\u2264\u20090.05), including IL\u20104\/IL\u201013 pathways and Wnt\/\u03b2\u2010catenin signalling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The lack of wound healing, microbiome dysbiosis and increased tumour susceptibility are all sustained by these dysfunctional methylomes, hopefully, capable to be targeted in the next future. Since methylome describes and summarizes genetic and environmental contributions, these data may represent a further step towards a feasible precision medicine also for HS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19286","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T13:44:05Z","timestamp":1687268645000},"page":"2109-2123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Hidradenitis suppurativa presents a methylome dysregulation capable to explain the pro\u2010inflammatory microenvironment: Are\u00a0these<scp>DNA<\/scp>methylations potential therapeutic targets?"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6617-5634","authenticated-orcid":false,"given":"Uppala","family":"Radhakrishna","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Oakland University William Beaumont School of Medicine Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uppala","family":"Ratnamala","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, School of Sciences Gujarat University Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1339-6492","authenticated-orcid":false,"given":"Devendrasinh D.","family":"Jhala","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, School of Sciences Gujarat University Ahmedabad India"},{"name":"Department of Zoology School of Sciences, Gujarat University Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya V.","family":"Uppala","sequence":"additional","affiliation":[{"name":"College of Information Science &amp; Technology The University of Nebraska at Omaha, Peter Kiewit Institute Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaren","family":"Vedangi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research KIMS ICON Hospital, A Unit of ICON Krishi Institute Medical Sciences Visakhapatnam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maulikkumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Bioinformatics Gujarat University Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Vadsaria","sequence":"additional","affiliation":[{"name":"Bioinformatics Gujarat University Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology B.J. 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