{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:58:14Z","timestamp":1792123094205,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The risk of infections among patients with psoriasis undergoing interleukin (IL)\u201023 inhibitors (IL\u201023i) and IL\u201017 inhibitors (IL\u201017i) is yet to be exhaustively determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the risk of infectious complications in patients with psoriasis managed by IL\u201023i and IL\u201017i with tumour necrosis factor inhibitors (TNFi) as a comparator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A global cohort study comprised two distinct analyses comparing patients with psoriasis under different therapeutic modalities; (i) new users of IL\u201023i (<jats:italic>n<\/jats:italic>\u2009=\u20095272) versus TNFi (<jats:italic>n<\/jats:italic>\u2009=\u20095272) and (ii) new users of IL\u201017i (<jats:italic>n<\/jats:italic>\u2009=\u200915,160) versus TNFi (<jats:italic>n<\/jats:italic>\u2009=\u200915,160). Study groups were compared regarding the risk of 26 different infections. Propensity score matching was conducted to optimize between\u2010group comparability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients under IL\u201023i had a lower risk of otitis media (HR, 0.66; 95% CI, 0.44\u20130.97), encephalitis (HR, 0.18; 95% CI, 0.04\u20130.78), herpes zoster (HZ; HR, 0.58; 95% CI, 0.41\u20130.82), hepatitis B virus (HBV) reactivation (HR, 0.24; 95% CI, 0.12\u20130.47), cytomegalovirus (HR, 0.25; 95% CI, 0.07\u20130.86), influenza (HR, 0.52; 95% CI, 0.38\u20130.71) and parasitic diseases (HR, 0.78; 95% CI, 0.64\u20130.95). IL\u201017i was associated with a decreased risk of pneumonia (HR, 0.76; 95% CI, 0.68\u20130.85), septicaemia (HR, 0.84; 95% CI, 0.72\u20130.97), upper respiratory tract infection (HR, 0.84; 95% CI, 0.77\u20130.92), HZ (HR, 0.79; 95% CI, 0.67\u20130.92), HBV (HR, 0.59; 95% CI, 0.46\u20130.76) and hepatitis C virus (HR, 0.71; 95% CI, 0.57\u20130.88) reactivation, cytomegalovirus (HR, 0.58; 95% CI, 0.36\u20130.93), Epstein\u2013Barr virus (HR, 0.38; 95% CI, 0.19\u20130.75), influenza (HR, 0.70; 95% CI, 0.61\u20130.81) and parasitic diseases (HR, 0.80; 95% CI, 0.72\u20130.88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with TNFi, IL\u201023i and IL\u201017i are associated with decreased risk of several infectious diseases. These agents might be preferred in patients with susceptibility to infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19328","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T12:20:01Z","timestamp":1689769201000},"page":"2319-2326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Evaluating the risk of infections under interleukin 23 and interleukin 17 inhibitors relative to tumour necrosis factor inhibitors \u2013 A population\u2010based study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-9151","authenticated-orcid":false,"given":"Khalaf","family":"Kridin","sequence":"first","affiliation":[{"name":"L\u0171beck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Unit of Dermatology and Skin Research Laboratory, Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henner","family":"Zirpel","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Inflammation Medicine University\u2010Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Mruwat","sequence":"additional","affiliation":[{"name":"Unit of Dermatology and Skin Research Laboratory, Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"L\u0171beck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diamant","family":"Thaci","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Inflammation Medicine University\u2010Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32549\u20106"},{"key":"e_1_2_9_3_1","unstructured":"WHO.Global report on ageism. 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