{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:19:01Z","timestamp":1791231541986,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Viral warts are common infectious skin disease induced by human papillomavirus (HPV). Lasers have been used for warts treatment in recent years with variable success rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to prospectively evaluate combined treatment with Er:YAG laser and long\u2010pulsed Nd:YAG laser compared to Er:YAG laser for the treatment of recalcitrant warts after one session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study included 240 lesions from 24 patients. All the lesions were diagnosed clinically as recalcitrant warts after failure of topical treatment and cryotherapy. About 120 lesions underwent a combined therapy of Er:YAG and long\u2010pulsed (LP) Nd:YAG lasers, and the remaining 120 lesions underwent Er:YAG laser therapy only. The clearance rate was evaluated 5\u2009weeks after and classified by three\u2010graded evaluation: complete response, partial response and poor response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clearance rate in the combined Er:YAG\u2009+\u2009LP Nd:YAG lasers group was, statistically significant, higher than that of the Er:YAG laser group (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). The complete response rate was 48% (58 of 120 warts) for the Er:YAG +LP Nd:YAG lasers group and only 29% (35 of 120 warts) for the Er:YAG laser group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of Er:YAG and long\u2010pulsed Nd:YAG lasers is more effective than Er:YAG laser alone in treating recalcitrant warts after single session.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19388","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T03:19:45Z","timestamp":1690946385000},"page":"2569-2574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of combined treatment with Er:<scp>YAG<\/scp> laser and long\u2010pulsed Nd:<scp>YAG<\/scp> laser for the treatment of recalcitrant warts: A\u00a0prospective randomized controlled trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8045-0682","authenticated-orcid":false,"given":"B.","family":"Jiryis","sequence":"first","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus  Haifa Israel"},{"name":"Bruce Rappaport Faculty of Medicine Technion Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Avitan\u2010Hersh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus  Haifa Israel"},{"name":"Bruce Rappaport Faculty of Medicine Technion Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Mirmovich","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Judith\u00a0Nevet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus  Haifa Israel"},{"name":"Bruce Rappaport Faculty of Medicine Technion Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-2807","authenticated-orcid":false,"given":"Z.","family":"Khamaysi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus  Haifa Israel"},{"name":"Bruce Rappaport Faculty of Medicine Technion Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13593"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14671"},{"key":"e_1_2_10_4_1","first-page":"187","article-title":"CO2 laser therapy versus cryotherapy in treatment of genital warts; 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