{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:09:43Z","timestamp":1792271383051,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Penile cancer is rising in most European countries. Several risk factors have been identified, namely human papillomavirus (HPV) infection. However, the exact role of HPV in penile cancer carcinogenesis is still unknown. Clarifying the contribution of HPV in penile cancer is crucial as it may improve prevention and treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the characteristics of patients with penile cancer and penile intraepithelial neoplasia (PeIN), evaluate the prevalence of HPV\u2010DNA in tumour tissue and identify differences between patients with and without HPV\u2010DNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective observational study including patients with histological diagnosis of penile squamous cell carcinoma (SCC) or PeIN between 2012 and 2021 in a university hospital was carried out. HPV analysis was performed using Anyplex\u2122 II HPV28 Detection that detects and identifies 28 HPV types. (sensitivity of 95.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 25 patients were included. Most of the tumours identified were invasive SCC (<jats:italic>n<\/jats:italic>\u2009=\u200911) and SCC in situ (PeIN 3) (<jats:italic>n<\/jats:italic>\u2009=\u20098). PeIN1\/2 was found in the remaining six patients. HPV\u2010DNA was tested in all tissue specimens and was detected in 18 of them. High risk HPV DNA was identified in all positive HPV samples, except one. HPV types included in the nonavalent HPV vaccine were identified in 16 of the 18 samples positive for HPV\u2010DNA. Stratifying patients according to HPV\u2010DNA detection, we found that patients with HPV\u2010DNA were younger (57.5\u2009years vs. 70\u2009years, <jats:italic>p<\/jats:italic>\u2009=\u20090.047), less likely to have phimosis (5.8% vs. 42.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.022) and more likely to have PeIN lesions than invasive SCC (85.7% vs. 27.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows a prevalence of HPV\u2010DNA in penile SCC and premalignant lesions of 45.5% and 92.9%, respectively. Identifying HPV involvement in SCC and PeIN pathology has the potential to guide treatment and enhance follow\u2010up strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19393","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T03:23:50Z","timestamp":1690946630000},"page":"186-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association between <scp>HPV<\/scp> infection and penile cancer and penile intraepithelial neoplasia: A retrospective observational study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3247-2470","authenticated-orcid":false,"given":"Maria Jose","family":"Guimaraes","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Hospital de Braga  Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Macieira","sequence":"additional","affiliation":[{"name":"Microbiology, Department of Pathology, Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lisboa","sequence":"additional","affiliation":[{"name":"Microbiology, Department of Pathology, Faculty of Medicine University of Porto  Porto Portugal"},{"name":"Department of Dermatovenereology Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"CINTESIS \u2013 Centre for Health Technology and Services Research, Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2196\/34874"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.07.088"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2009.036061"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599.2012.677473"},{"key":"e_1_2_11_6_1","first-page":"646","article-title":"The diagnosis and treatment of penile cancer","volume":"115","author":"Hakenberg OW","year":"2018","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.02.029"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13871"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30682-X"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001606"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.12.973"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.06.010"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-018-0083-0"},{"key":"e_1_2_11_14_1","unstructured":"EUA Guidelines.EDn. Presented at the EUA Annual Congress Amsterdam 2022. ISBN 978\u201094\u201092671\u201016\u20105. 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