{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:35:55Z","timestamp":1772735755999,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Guselkumab is a monoclonal antibody that blocks the IL\u201023 pathway with proven efficacy and tolerability in the treatment of moderate\u2010to\u2010severe plaque psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the persistence, effectiveness and safety of guselkumab in patients with moderate\u2010to\u2010severe psoriasis in real clinical practice in Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SPRING was a Phase IV, retrospective and non\u2010interventional study analysing patients with moderate\u2010to\u2010severe plaque psoriasis who had initiated guselkumab under clinical practice conditions at least 12\u2009months before inclusion in the study. The primary endpoint was persistence (non\u2010persistence: discontinuation or interruption \u226590\u2009days). Effectiveness was assessed using the Psoriasis Area Severity Index (PASI) and Investigator Global Assessment (IGA). Dermatology Life Quality Index (DLQI) and safety were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 284 patients were included between September 2020 and June 2021. The 1\u2010year probability of persistence was 89.6% (86.1%\u201393.3%). The 1\u2010year probability of persistence was also calculated according to prior biologic treatment, being 90.3% for biologic\u2010na\u00efve patients and 89.5% for patients who received one or more biologic therapies before guselkumab. Additionally, patients were also classified based on the frequency of the administration of guselkumab treatment; the 1\u2010year probability of persistence was 91.9% in patients receiving guselkumab according to the Summary of Product Characteristics and 89.3% in patients with lengthened intervals of administration. After 1\u2009year, PASI 90 was achieved by 56.4% of patients, IGA 0\/1 response and BSA &lt;3% were achieved by 65.5% and 77.8% of patients, respectively, and 65.8% achieved a minimal clinically significant difference (&gt;4\u2010point reduction) in the DLQI score at 1\u2009year. Twenty\u2010six adverse reactions (4 of them serious) were reported in 16 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that guselkumab has high persistence in real clinical practice in Spain, independently of the previous biologic treatments and changes in the frequency of treatment. Effectiveness and safety are consistent with previously published data.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19403","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T02:37:33Z","timestamp":1691807853000},"page":"27-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Persistence and effectiveness of guselkumab treatment in patients with moderate\u2010to\u2010severe plaque psoriasis in a non\u2010interventional real\u2010world setting: The <scp>SPRING<\/scp> study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-0952","authenticated-orcid":false,"given":"L.","family":"Puig","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-1260","authenticated-orcid":false,"given":"E.","family":"Daud\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Dermatology Instituto de Investigaci\u00f3n Sanitaria (IIS\u2010HP) Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9310-5853","authenticated-orcid":false,"given":"M.","family":"Cuervas\u2010Mons","sequence":"additional","affiliation":[{"name":"Medical Department Janssen Cilag, S.A.  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