{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:27:29Z","timestamp":1793302049065,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017655","name":"Incyte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is a chronic autoimmune disease resulting in skin depigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study assessed the prevalence, disease burden and treatment of vitiligo in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>VIOLIN was a cross\u2010sectional study nested in the national CONSTANCES cohort, which consists of randomly selected adults aged 18\u201369\u2009years in France. In VIOLIN, longitudinal data were collected prospectively from 158,898 participants during 2012\u20132018 and linked to the National Health Data System (SNDS), a healthcare utilization database. Patients with physician\u2010diagnosed vitiligo were matched (1:3) with control participants based on age, sex, geographic region, year of inclusion and skin phototype. Patients completed a questionnaire in 2022 to collect disease characteristics, disease burden and quality\u2010of\u2010life (QoL) data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitiligo prevalence was 0.71% (681\/95,597) in 2018. The mean age in the vitiligo population was 51.2\u2009years; 51.4% were women. Most patients (63%) were diagnosed before age 30\u2009years, mainly by dermatologists (83.5%). Most patients (81.1%) had visible lesions (i.e. on face, hands). Vitiligo was limited to &lt;10% of the body surface area (BSA) in 85.8% of patients. Comorbidities including thyroid disease (18.0% vs. 9.0%), psoriasis (13.7% vs. 9.7%), atopic dermatitis (12.4% vs. 10.3%), depression (18.2% vs. 14.6%) and alopecia areata (4.3% vs. 2.4%) were significantly more common in patients with vitiligo versus matched controls (<jats:italic>n<\/jats:italic>\u2009=\u20092043). QoL was significantly impaired in patients with &gt;5% BSA involvement or visible lesions, particularly with \u226510% facial involvement. Vitiligo\u2010specific instruments (i.e. Vitiligo Impact Patient scale and Vitiligo\u2010specific QoL instrument) were more sensitive to QoL differences among subgroups versus general skin instruments, and generic instruments were least sensitive. Most patients (83.8%) did not receive any prescribed treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with vitiligo in France have a high disease burden, particularly those with visible lesions or higher BSA involvement. Most patients are not receiving treatment, highlighting the need for new effective treatments and patient\/physician education.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19447","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:01:28Z","timestamp":1692676888000},"page":"2249-2258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Vitiligo patient population and disease burden in France: <scp>VIOLIN<\/scp> study results from the <scp>CONSTANCES<\/scp> cohort"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-4589","authenticated-orcid":false,"given":"Khaled","family":"Ezzedine","sequence":"first","affiliation":[{"name":"Henri Mondor University Hospital and Universit\u00e9 Paris\u2010Est Cr\u00e9teil Val de Marne  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-0908","authenticated-orcid":false,"given":"Julien","family":"Seneschal","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatric Dermatology National Reference Center for Rare Skin Disorders, H\u00f4pital Saint Andr\u00e9, CNRS, UMR\u20105164, ImmunoConcEpT  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Da\u00a0Silva","sequence":"additional","affiliation":[{"name":"Incyte Biosciences France  Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Pr\u00e9aubert","sequence":"additional","affiliation":[{"name":"Medconsult  Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lamblin","sequence":"additional","affiliation":[{"name":"Association Fran\u00e7aise du Vitiligo  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Delattre","sequence":"additional","affiliation":[{"name":"Incyte Biosciences International S\u00e0rl  Morges Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Emery","sequence":"additional","affiliation":[{"name":"CEMKA  Bourg\u2010La\u2010Reine France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Nevoret","sequence":"additional","affiliation":[{"name":"CEMKA  Bourg\u2010La\u2010Reine France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Finzi","sequence":"additional","affiliation":[{"name":"Incyte Biosciences France  Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-2680","authenticated-orcid":false,"given":"St\u00e9phane","family":"Bou\u00e9e","sequence":"additional","affiliation":[{"name":"CEMKA  Bourg\u2010La\u2010Reine France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6570","authenticated-orcid":false,"given":"Thierry","family":"Passeron","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Nice, Universit\u00e9 C\u00f4te d'Azur  Nice France"},{"name":"INSERM U1065, C3M, Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03765.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00631-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18257"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S304155"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11197.x"},{"key":"e_1_2_9_8_1","unstructured":"Incyte Biosciences Distribution B.V. 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