{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:29:32Z","timestamp":1790832572784,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["RUNDENG 20201640\u201000222937"],"award-info":[{"award-number":["RUNDENG 20201640\u201000222937"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dengue is an arbovirosis affecting nearly 4 billion people worldwide. Since 2018, dengue has been re\u2010emerging in Reunion Island. The incidence of mucocutaneous manifestations varies according to the studies and is generally called \u2018rash\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the prevalence of different mucocutaneous symptoms and describe the characteristics of patients developing these symptoms and the clinical signs associated with severe dengue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted in 2019 at the University Hospital of La R\u00e9union, in patients presenting a positive PCR for dengue. Descriptive analyses were performed. All cases in the prospective study were examined by a dermatologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 163 cases were included. The prevalence of mucocutaneous signs was 80.4%. A pruritus was reported in 33.7% cases, an erythematous rash in 29.4% and a mouth involvement including lip, tongue, cheek, angular cheilitis, pharyngitis, mouth ulcer and gingivitis in 31.3%. Most of symptoms appeared in the first days, but some of them could disappear only after the 3rd week. Mucocutaneous signs were not associated with a severe dengue fever (<jats:italic>p<\/jats:italic>\u2009=\u20090.54), but ecchymotic purpura was (<jats:italic>p<\/jats:italic>\u2009=\u20090.037). In multivariate analysis, skin involvement was associated with flu\u2010like syndrome (headache, pharyngitis, rachis pain) and patient required rehydration but not invasive reanimation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This work confirms the high prevalence of skin symptoms in dengue disease, but also their wide diversity. The mucocutaneous involvement of dengue fever appears to be accompanied by a pronounced flu\u2010like syndrome in people without severity, but careful examination to identify ecchymotic purpura or sign of dehydration in the mucous membranes would better identify cases that may worsen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19453","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T20:46:00Z","timestamp":1692823560000},"page":"191-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Descriptive and comparative analysis of mucocutaneous manifestations in patients with dengue fever: A prospective study"],"prefix":"10.1111","volume":"38","author":[{"given":"C.","family":"Fera","sequence":"first","affiliation":[{"name":"CHU R\u00e9union, Service des Maladies Infectieuses \u2013 Dermatologie  Saint Pierre La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Maillard","sequence":"additional","affiliation":[{"name":"Inserm CIC1410, CHU R\u00e9union  Saint Pierre La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Joly","sequence":"additional","affiliation":[{"name":"CHU R\u00e9union, Service des Maladies Infectieuses \u2013 Dermatologie  Saint Pierre La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Diallo","sequence":"additional","affiliation":[{"name":"CHU R\u00e9union, Service des Maladies Infectieuses \u2013 Dermatologie  Saint Pierre La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mavingui","sequence":"additional","affiliation":[{"name":"UMR PIMIT, CNRS 9192, INSERM 1187, IRD 249, Universit\u00e9 de La R\u00e9union  Saint\u2010Denis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Koumar","sequence":"additional","affiliation":[{"name":"CHU R\u00e9union, Service des Maladies Infectieuses \u2013 Dermatologie  Saint Pierre La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cabi\u00e9","sequence":"additional","affiliation":[{"name":"CHU Martinique, Service des Maladies Infectieuses, Fort de France  Martinique France"},{"name":"Inserm CIC1424, CHU de Martinique  Fort\u2010de\u2010France France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-8869","authenticated-orcid":false,"given":"A.","family":"Bertolotti","sequence":"additional","affiliation":[{"name":"CHU R\u00e9union, Service des Maladies Infectieuses \u2013 Dermatologie  Saint Pierre La R\u00e9union France"},{"name":"Inserm CIC1410, CHU R\u00e9union  Saint Pierre La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1110265"},{"key":"e_1_2_12_3_1","unstructured":"SPF.Surveillance de la dengue \u00e0 La R\u00e9union. 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