{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:26Z","timestamp":1787015426162,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kligman's trio (KT), combining hydroquinone, retinoic acid and corticosteroid, is considered as the gold standard treatment of melasma. Its efficacy has never been matched before, but it is tempered by frequent adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the efficacy and tolerance of a New Trio (NT) combination with isobutylamido\u2010thiazolyl\u2010resorcinol, retinoic acid and cortosteroid compared to KT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a 24\u2010week monocentric trial, randomized, double\u2010blind, controlled versus KT, with 40 melasma patients. NT and KT were applied for 12\u2009weeks and associated with the same sunscreen applied for 24\u2009weeks. The primary endpoint was the modified Melasma Area Severity Index (mMASI) at 12\u2009weeks. Patient quality of life was investigated using MelasQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 12\u2009weeks, KT and NT groups both demonstrated a significant improvement in mMASI, respectively \u22122.84 (SE 0.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0002) and \u22124.33 (SE 0.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The mean difference between the two groups was \u22121.49 (IC 95% \u22123.52 to 0.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.14). MelasQoL improvement was \u22126.66 (SE 3.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0515) with KT and \u221212.57 (SE 3.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0006) with NT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The NT combination appears to be an effective treatment option for treating melasma and could be considered as a well\u2010tolerated alternative to KT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.19455","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T22:40:48Z","timestamp":1692916848000},"page":"2601-2607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy and safety of a novel triple combination cream compared to Kligman's trio for melasma: A 24\u2010week double\u2010blind prospective randomized controlled trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1796-2076","authenticated-orcid":false,"given":"Cl\u00e9mence","family":"Bertold","sequence":"first","affiliation":[{"name":"Department of Dermatology, CHU Nice Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Fontas","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Cimiez Hospital, CHU Nice Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2062-7543","authenticated-orcid":false,"given":"Tanya","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Nice Universit\u00e9 C\u00f4te d'Azur  Nice 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Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire Universit\u00e9 C\u00f4te d'Azur  Nice 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