{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:45:52Z","timestamp":1781754352174,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lentigo maligna melanoma is mainly localized in the head and neck region in elderly patients. Due to its slow horizontal growth, it has a good prognosis compared to other melanoma subtypes, but specific data are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate sentinel lymph node biopsy in lentigo maligna melanoma under local anaesthesia and to discuss the benefit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Investigation of patients with lentigo maligna melanoma and tumour thickness \u22651\u2009mm treated at the Department of Dermatology, University Medical Centre Tuebingen, between January 2008 and October 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 204 patients (126 SLNB, 78 non\u2010SLNB) with a median age of 75.7\u2009years (SLNB: 73.3\u2009years, non\u2010SLNB: 79.7\u2009years) could be included. Sixteen of 126 (12.7%) sentinel lymph nodes were positive. Five\u2010year overall survival was 87.9% (88.5% SLNB; 87.4% non\u2010SLNB) and 5\u2010year distant metastasis\u2010free survival was 85.8% (85.4% SLNB; 86.7% non\u2010SLNB). There was no significant difference for distant metastasis\u2010free survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.861) and overall survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.247) between patients with and without sentinel lymph node biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sentinel lymph node biopsy in lentigo maligna melanoma under local anaesthesia is a safe and simple method, even in very old patients. However, LMM has a very good 5\u2010year overall survival. In high\u2010risk patients with high tumour thickness and\/or ulceration, adjuvant immunotherapy can now be offered without the need to perform this procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19456","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T20:44:36Z","timestamp":1692823476000},"page":"84-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sentinel lymph node biopsy for lentigo maligna melanoma under local anaesthesia"],"prefix":"10.1111","volume":"38","author":[{"given":"Julia","family":"Huynh","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin 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