{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:17:24Z","timestamp":1785172644081,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tildrakizumab is a humanized, IgG1\/\u03ba antibody that interacts with the p19 subunit of interleukin 23. It is approved for the treatment of moderate\u2010to\u2010severe plaque psoriasis. Real\u2010world evidence on the effectiveness and safety of tildrakizumab is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the effectiveness and safety of tildrakizumab at 24\u2009weeks in patients with moderate\u2010to\u2010severe plaque psoriasis in routine clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective, observational, multicentre study including adult patients with moderate\u2010to\u2010severe plaque psoriasis treated with tildrakizumab under real\u2010life conditions. Patient data were extracted from anonymized electronic medical records. Statistical analysis was performed using SPSS22.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 190 patients were included. About 53.9% were men with a mean age of 51.45 (SD 3.9) and a mean BMI of 29.13 (SD 6.21). About 79.8% (132 out of 190) of patients had previously received biological therapy (BT) and 17.3% (33 out of 191) had psoriatic arthritis. Baseline PASI was 10.7 (SD 6.53). Up to 109 patients reached Week 24 and at this point mean baseline PASI decreased to 1.7 (SD 4.8), representing an 88.79% mean PASI reduction. At 6\u2009months, 87.1% and 40.3% of the treated patients achieved PASI \u22643 and \u22641, respectively. At Week 24 mean BSA decreased from 13.2 (SD 10.07) to 1.6 (SD 4.40) and mean DLQI went from 12.5 (SD 7.12) to 1.2 (SD 3.27). Multivariate analysis showed no differences when effectiveness was correlated with gender, obesity, psoriatic arthritis or prior exposure to BT. The rate of adverse events (AE) was 5.9% (11 out of 190), where infections were the most frequent AE (4 out of 11). One patient suffered a haemorrhagic ictus and one patient died due to causes unrelated to the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tildrakizumab was effective and safe in a large cohort of patients with moderate\u2010to\u2010severe plaque psoriasis treated in a routine clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19468","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:28:31Z","timestamp":1693009711000},"page":"2517-2525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effectiveness and safety of tildrakizumab for the treatment of psoriasis in real\u2010world settings at 24\u2009weeks: A retrospective, observational, multicentre study by the Spanish Psoriasis Group"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-863X","authenticated-orcid":false,"given":"Sonsoles","family":"Berenguer\u2010Ruiz","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario de la Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Aparicio\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de la Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Herranz\u2010Pinto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Ru\u00edz\u2010Villaverde","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario San Cecilio  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-963X","authenticated-orcid":false,"given":"Anna","family":"L\u00f3pez\u2010Ferrer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Santos\u2010Juanes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Central de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Rodr\u00edguez\u00a0Fern\u00e1ndez\u2010Freire","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Virgen del Rocio  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Hospital\u2010Gil","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Puerta de Hierro  Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-1435","authenticated-orcid":false,"given":"Salvador","family":"Arias\u2010Santiago","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Virgen de las Nieves Hospital  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Carretero\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Gran Canaria Dr. Negr\u00edn  Las Palmas Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Mateu\u2010Puchades","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Doctor Peset  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ferran","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5935-356X","authenticated-orcid":false,"given":"Elena","family":"del Alc\u00e1zar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Germans Trias i Pujol  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Santos\u2010Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Virgen de los Lirios  Alcoy Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Garcia\u2010Latasa\u00a0de\u00a0Aranibar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Royo Villanova Hospital  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-7320","authenticated-orcid":false,"given":"Isabel","family":"Belinch\u00f3n\u2010Romero","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8060-4784","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Gonz\u00e1lez\u2010Cantero","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario de Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1093-6411","authenticated-orcid":false,"given":"Diana","family":"Ru\u00edz\u2010Genao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Fundaci\u00f3n Alcorcon  Madrid 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