{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:38:46Z","timestamp":1771047526658,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne fulminans (AF) is a rare severe acne entity. Although occasionally reported, it is unclear whether AF development is associated with oral isotretinoin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the occurrence of isotretinoin\u2010associated AF, clinical characteristics and prognosis at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An international, multicentre, retrospective study was performed in eight hospitals following the call of the EADV Task Force on Acne, Rosacea and Hidradenitis Suppurativa (ARHS). Characteristics of patients treated with isotretinoin before the development of AF (isotretinoin\u2010associated acne fulminans, IAF) were compared with non\u2010IAF (NAF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine patients diagnosed with AF from 2008 to 2022 were included (mean age 16.4\u2009years, SD 2.9, 77.6% male). \u0391rthralgias\/arthritis occurred in 11 patients (22.9%). AF occurred without any previous acne treatment in 26.5% of the patients. Overall, 28 patients (57.1%) developed AF after oral isotretinoin intake (IAF group), while the remaining 21 patients (42.9%) developed AF without previous oral isotretinoin administration (NAF group). IAF occurred after a median duration of isotretinoin treatment of 45\u2009days (IQR: 30, 90). Patients with IAF were more frequently male compared to patients with NAF (89.3% vs. 61.9%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.023). There were no differences in patients with IAF versus NAF in patient age, the duration of pre\u2010existing acne, a family history of AF, the distribution of AF lesions or the presence of systemic symptoms or arthralgias. Regarding the management of AF, patients with IAF were treated more frequently with prednisolone (96.2%) compared to those with NAF (70%; <jats:italic>p<\/jats:italic>\u2009=\u20090.033) and less frequently with isotretinoin (32.1%) compared to NAF (85.7%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). At a median follow\u2010up of 2.2\u2009years, 76.4% of patients were free of AF and scarring was present in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No specific clinical or demographic characteristics of IAF compared with NAF could be detected, a fact that does not support IAF as a district clinical entity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19477","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T01:49:27Z","timestamp":1693360167000},"page":"197-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Isotretinoin\u2010associated acne fulminans: A multicentre, retrospective study of the European Academy of Dermatology and Venereology Task Force on Acne, Rosacea and Hidradenitis Suppurativa"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-3410","authenticated-orcid":false,"given":"Clio","family":"Dessinioti","sequence":"first","affiliation":[{"name":"1st Department of Dermatology\u2010Venereology National and Kapodistrian University of Athens, Andreas Sygros Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-5825","authenticated-orcid":false,"given":"Brigitte","family":"Dr\u00e9no","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-4600","authenticated-orcid":false,"given":"Vincenzo","family":"Bettoli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Dermatology University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Secil","family":"Vural","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Ko\u00e7 University School of Medicine  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6817-606X","authenticated-orcid":false,"given":"Piotr","family":"Brzezinski","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Medical Emergency, Faculty of Health Sciences Pomeranian University  Slupsk Poland"},{"name":"Department of Dermatology Provincial Specialist Hospital  Slupsk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aude","family":"Nassif","sequence":"additional","affiliation":[{"name":"Institut Pasteur  Paris 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