{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:19:14Z","timestamp":1787509154693,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic ulcers, especially venous leg ulcers, are a major burden on the healthcare system. To date there are only few non\u2010invasive established procedures for evaluation of blood perfusion in wounds. Dynamic optical coherence tomography (D\u2010OCT) provides images of the skin's superficial vascularisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to investigate if and how the D\u2010OCT measurement of chronic wounds can provide new information about the vascularisation during the healing process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined 16 venous ulcers over 16\u2009weeks and evaluated the vessel morphology and density using D\u2010OCT at the wound bed, borders, two centimetres adjacent to the wound und at non\u2010ulcerated skin on the contralateral leg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In D\u2010OCT scans\n                      <jats:italic>clumps<\/jats:italic>\n                      were unique and the most common vessel type in the wound area of venous ulcers, whereas\n                      <jats:italic>lines<\/jats:italic>\n                      and\n                      <jats:italic>serpiginous vessels<\/jats:italic>\n                      were the most common in non\u2010ulcerated skin. At the wound border\n                      <jats:italic>mottle<\/jats:italic>\n                      and\n                      <jats:italic>cluster<\/jats:italic>\n                      patterns occurred more frequently. Healthy skin showed a significant increase of\n                      <jats:italic>mesh<\/jats:italic>\n                      pattern. Vessel density significantly increased at the wound area compared to non\u2010ulcerated skin. During the healing process the wound border showed the most vascular changes while only an increase in\n                      <jats:italic>curves<\/jats:italic>\n                      was observed in the wound centre. Non\u2010healing wounds had fewer\n                      <jats:italic>dots<\/jats:italic>\n                      and\n                      <jats:italic>blobs<\/jats:italic>\n                      at the borders, fewer\n                      <jats:italic>dots, coils, clumps, lines<\/jats:italic>\n                      and\n                      <jats:italic>serpiginous vessels<\/jats:italic>\n                      at the centre and fewer\n                      <jats:italic>dots<\/jats:italic>\n                      in adjacent skin. Temperature analysis showed higher temperatures in non\u2010ulcerated skin, followed by the wound margin and centre. Non\u2010healing wounds showed the lowest temperatures in the wound centre.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results highlight the non\u2010invasive use of D\u2010OCT for the examination and monitoring of wound healing in chronic venous ulcers. D\u2010OCT imaging of blood vessels may offer the potential to detect disorders of wound healing at an early stage, differentiate ulcers of different genesis and to tailor more individualized, patient\u2010oriented therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.19496","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T21:05:20Z","timestamp":1693947920000},"page":"223-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dynamic optical coherence tomography of chronic venous ulcers"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-6188","authenticated-orcid":false,"given":"Jennifer Jahel","family":"V\u00e9lez\u00a0Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4649-3405","authenticated-orcid":false,"given":"Maximilian","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2054-9052","authenticated-orcid":false,"given":"Stefan","family":"Schiele","sequence":"additional","affiliation":[{"name":"Institute of Mathematics University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8730-7596","authenticated-orcid":false,"given":"Anna","family":"Rubeck","sequence":"additional","affiliation":[{"name":"Institute of Mathematics University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4426-6252","authenticated-orcid":false,"given":"Gernot","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Mathematics University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6099-7418","authenticated-orcid":false,"given":"Julia","family":"Welzel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7619","authenticated-orcid":false,"given":"Sandra","family":"Schuh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2004.13.6.26670"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-014-0626-7"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12387"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-015-3607-z"},{"key":"e_1_2_12_6_1","first-page":"158","article-title":"Dynamic OCT \u2010 what do the vessels tell us?","volume":"46","author":"Schuh S","year":"2020","journal-title":"Aktuel Dermatol"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-46389-5_4"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734618821015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1152-x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.6.061224"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19629.x"},{"key":"e_1_2_12_12_1","unstructured":"MichelsonDiagnostics.VivoSight OCT scanner \u2013 Technische Daten.https:\/\/de.vivosight.com\/forschungs\u2010anwender\/vivosight\u2010scanner\/#technische\u2010daten. 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