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This project mapped consensus across dermatologists, obstetricians and patients in Northwestern Europe to build practical advice for managing AD with systemic anti\u2010inflammatory treatment in men and women of reproductive age. Twenty\u2010one individuals (sixteen dermatologists, two obstetricians and three patients) participated in a two\u2010round Delphi process. Full consensus was reached on 32 statements, partial consensus on four statements and no consensus on four statements. Cyclosporine A was the first\u2010choice long\u2010term systemic AD treatment for women preconception, during pregnancy and when breastfeeding, with short\u2010course prednisolone for flare management. No consensus was reached on second\u2010choice systemics preconception or during pregnancy, although during breastfeeding dupilumab and azathioprine were deemed suitable. It may be appropriate to discuss continuing an existing systemic AD medication with a woman if it provides good disease control and its benefits in pregnancy outweigh its risks. Janus kinase (JAK) inhibitors, methotrexate and mycophenolate mofetil should be avoided by women during preconception, pregnancy and breastfeeding, with medication\u2010specific washout periods advised. For men preconception: cyclosporine A, azathioprine, dupilumab and corticosteroids are appropriate; a 3\u2010month washout prior to conception is desirable for methotrexate and mycophenolate mofetil; there was no consensus on JAK inhibitors. Patient and clinician education on appropriate (and inappropriate) AD treatments for use in pregnancy is vital. A shared\u2010care framework for interdisciplinary management of AD patients is advocated and outlined. This consensus provides interdisciplinary clinical guidance to clinicians who care for patients with AD before, during and after pregnancy. While systemic AD medications are used uncommonly in this patient group, considerations in this article may help patients with severe refractory AD.<\/jats:p>","DOI":"10.1111\/jdv.19512","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T16:31:25Z","timestamp":1694622685000},"page":"31-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Systemic anti\u2010inflammatory treatment of atopic dermatitis during conception, pregnancy and breastfeeding: Interdisciplinary expert consensus in Northern Europe"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0593-9925","authenticated-orcid":false,"given":"M.","family":"Deleuran","sequence":"first","affiliation":[{"name":"Department of Dermatology Aarhus University Hospital and Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"D\u00e9zfoulian","sequence":"additional","affiliation":[{"name":"Dermatology Department Li\u00e8ge University Hospital  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Elberling","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Department of Clinical Medicine, Herlev and Gentofte Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Knutar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Vaasa Central Hospital  Vaasa Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lapeere","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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