{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:59:12Z","timestamp":1793901552271,"version":"4.8.0"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis. Traditionally, the primary pathophysiologic factors in acne have been thought to be: (1) altered sebum production, (2) inflammation, (3) excess keratinization and (4) colonization with the commensal\n                    <jats:italic>Cutibacterium acnes<\/jats:italic>\n                    . However, the role of\n                    <jats:italic>C.\u2009acnes<\/jats:italic>\n                    has been unclear, since virtually all adults have\n                    <jats:italic>C.\u2009acnes<\/jats:italic>\n                    on their skin yet not all develop acne. In recent years, understanding of the role of\n                    <jats:italic>C.\u2009acnes<\/jats:italic>\n                    has expanded. It is still acknowledged to have an important place in acne pathogenesis, but evidence suggests that an imbalance of individual\n                    <jats:italic>C.\u2009acnes<\/jats:italic>\n                    phylotypes and an alteration of the skin microbiome trigger acne. In addition, it is now believed that\n                    <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    is also an actor in acne development. Together,\n                    <jats:italic>C.\u2009acnes<\/jats:italic>\n                    and\n                    <jats:italic>S.\u2009epidermidis<\/jats:italic>\n                    maintain and regulate homeostasis of the skin microbiota. Antibiotics, which have long been a staple of acne therapy, induce cutaneous dysbiosis. This finding, together with the long\u2010standing public health edict to spare antibiotic use when possible, highlights the need for a change in acne management strategies. One fertile direction of study for new approaches involves dermocosmetic products that can support epidermal barrier function and have a positive effect on the skin microbiome.\n                  <\/jats:p>","DOI":"10.1111\/jdv.19540","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T21:48:53Z","timestamp":1696110533000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Acne microbiome: From phyla to phylotypes"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-5825","authenticated-orcid":false,"given":"Brigitte","family":"Dreno","sequence":"first","affiliation":[{"name":"Dermatology Department INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302\/EMR6001, Nantes Universit\u00e9  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9428-0098","authenticated-orcid":false,"given":"Itaru","family":"Dekio","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Acne Treatment and Research Center  Morristown New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-8851","authenticated-orcid":false,"given":"Anne Laure","family":"Demessant","sequence":"additional","affiliation":[{"name":"La Roche Posay Laboratoire Dermatologique  Levallois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Ange","family":"Dagnelie","sequence":"additional","affiliation":[{"name":"Dermatology Department INSERM, CNRS, Immunology and New 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