{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:36:33Z","timestamp":1783488993466,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Line\u2010field confocal optical coherence tomography (LC\u2010OCT) is a new, valid means for a rapid and non\u2010invasive in\u00a0vivo examination of the epidermis and upper dermis, allowing digital interpretation and measurement of high\u2010resolution images on a cellular level. Given these properties, it may represent a valid tool for monitoring psoriasis during treatment, allowing a new method to set a precise objective severity of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate the potentialities of LC\u2010OCT in the non\u2010invasive monitoring of microscopical changes associated with moderate\u2013severe plaque psoriasis (PP) during the treatment with the most common biological drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We performed LC\u2010OCT imaging of PP lesions from 17 patients before and after 8\u2009weeks of treatment. The clinical severity of the single lesions was evaluated using a lesion score (LS), designed considering three parameters: erythema, desquamation and infiltration. LC\u2010OCT images were segmented by artificial intelligence and evaluated based on three microscopic criteria: the thickness of the stratum corneum, the thickness of the living epidermis and the undulation of the dermo\u2010epidermal junction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Line\u2010field confocal optical coherence tomography digital analysis allowed recognition and quantification of the three microscopic criteria, showing a reduction of all these during the follow\u2010up. Furthermore, a high correlation between change in LS and the thickness of the stratum corneum and the thickness of the living epidermis was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Line\u2010field confocal optical coherence tomography can non\u2010invasively monitor the response of PP to different treatments. Morphometric changes occurring in the psoriatic lesion during the 8\u2010week treatment period were identified by in\u00a0vivo LC\u2010OCT and measured by using artificial intelligence. Although future studies are required, based on these preliminary results, LC\u2010OCT may represent a valid potential tool for precise monitoring of therapeutic response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19568","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T09:47:55Z","timestamp":1697104075000},"page":"325-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Line\u2010field confocal optical coherence tomography: New insights for psoriasis treatment monitoring"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7852-8759","authenticated-orcid":false,"given":"C.","family":"Orsini","sequence":"first","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8301-9206","authenticated-orcid":false,"given":"E.","family":"Trovato","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-5236","authenticated-orcid":false,"given":"G.","family":"Cortonesi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pedrazzani","sequence":"additional","affiliation":[{"name":"DAMAE Medical  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-0342","authenticated-orcid":false,"given":"M.","family":"Suppa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tognetti","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-0659","authenticated-orcid":false,"given":"E.","family":"Cinotti","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12954-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10988.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03134.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S107514"},{"key":"e_1_2_11_7_1","first-page":"337","article-title":"Characterization of psoriasis in\u00a0vivo by reflectance confocal microscopy","volume":"30","author":"Gonz\u00e1lez S","year":"1999","journal-title":"J Med"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202100236"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18324"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18293"},{"issue":"3","key":"e_1_2_11_11_1","first-page":"190","article-title":"Inflammatory and infectious skin diseases in line\u2010field confocal optical coherence tomography: state of the art","volume":"158","author":"Donelli C","year":"2023","journal-title":"Ital J Dermatol Venerol"},{"issue":"6","key":"e_1_2_11_12_1","first-page":"4974","article-title":"Imaging techniques in the diagnosis and monitoring of psoriasis","volume":"18","author":"Grajdeanu IA","year":"2019","journal-title":"Exp Ther Med"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12062"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12150"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13235"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08582.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1961.36"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0216"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202000449"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.19568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T09:17:08Z","timestamp":1725355028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.19568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/jdv.19568"],"URL":"https:\/\/doi.org\/10.1111\/jdv.19568","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"assertion":[{"value":"2023-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}