{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:25Z","timestamp":1787015425987,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic debilitating disease with a significant burden of both organic and psychological comorbidities. It has been shown that certain telomere\u2010related genes (TRGs) affect a wide range of diseases, including HS and its associated comorbidities, but their exact role in HS pathogenesis is still unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether TRG methylomes can be used as biomarkers in HS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Illumina HumanMethylation450 BeadChip array, we examined methylation variations associated with TRGs in HS cases and age\u2010, sex\u2010 and ethnicity\u2010matched healthy controls. The study utilized integrated bioinformatics statistical methods, such as a false discovery rate (FDR), the area under the receiver operating characteristic curve (AUC) and principal component analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were a total of 585 different differentially methylated CpG sites identified in 585 TRGs associated with HS (474 hypomethylated and 111 hypermethylated) (FDR\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.05). A number of these CpGs have been identified as being involved in increased pain sensitivity including\n                      <jats:italic>EPAS1<\/jats:italic>\n                      ,\n                      <jats:italic>AHR<\/jats:italic>\n                      ,\n                      <jats:italic>CSNK1D<\/jats:italic>\n                      ,\n                      <jats:italic>DNMT1<\/jats:italic>\n                      ,\n                      <jats:italic>IKBKAP<\/jats:italic>\n                      ,\n                      <jats:italic>NOS3<\/jats:italic>\n                      ,\n                      <jats:italic>PLCB1<\/jats:italic>\n                      and\n                      <jats:italic>PRDM16<\/jats:italic>\n                      genes;\n                      <jats:italic>GABRB3<\/jats:italic>\n                      as a potential alcohol addiction marker;\n                      <jats:italic>DDB1<\/jats:italic>\n                      ,\n                      <jats:italic>NSMCE2 and HNRNPA2B1<\/jats:italic>\n                      associated with cancers. Pathway analysis identified 67 statistically significant pathways, including DNA repair, telomere maintenance, mismatch repair and cell cycle control (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The disruption of TRGs leads to the shortening of telomeres, which is associated with HS progression, ageing, cellular senescence and an increased risk of various diseases, including cancer and associated comorbidities, such as metabolic syndrome, cardiovascular disease and inflammatory disorders. Further research is necessary to better understand the underlying mechanisms and establish causal links between TRGs and HS. The present study is the first effort to comprehend potential pathomechanisms of sporadic HS cases concentrating on PBMC methylome since ours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.19586","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T21:58:42Z","timestamp":1698098322000},"page":"393-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hidradenitis suppurativa associated telomere\u2010methylome dysregulations in blood"],"prefix":"10.1111","volume":"38","author":[{"given":"Uppala","family":"Radhakrishna","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Oakland University William Beaumont School of Medicine  Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uppala","family":"Ratnamala","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, School of Sciences Gujarat University  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1339-6492","authenticated-orcid":false,"given":"Devendrasinh D.","family":"Jhala","sequence":"additional","affiliation":[{"name":"Department of Zoology, School of Sciences Gujarat University  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya V.","family":"Uppala","sequence":"additional","affiliation":[{"name":"College of Information Science &amp; Technology, Peter Kiewit Institute the University of Nebraska at Omaha  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaren","family":"Vedangi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, KIMS ICON Hospital A Unit of ICON Krishi Institute Medical Sciences  Visakhapatnam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Saiyed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oakland University William Beaumont School of Medicine  Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maulikkumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Bioinformatics Gujarat University  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Vadsaria","sequence":"additional","affiliation":[{"name":"Bioinformatics Gujarat University  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma R.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology BJ Medical College Institute of Medical Post\u2010Graduate Studies and Research  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh M.","family":"Rawal","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, School of Sciences Gujarat University  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo R.","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Unit of Dermatology and Cosmetology IRCCS San Raffaele Hospital  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"McGonagle","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor B. E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Damiani","sequence":"additional","affiliation":[{"name":"Unit of Dermatology and Cosmetology IRCCS San Raffaele Hospital  Milano Italy"},{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan  Milan Italy"},{"name":"Italian Center of Precision Medicine and Chronic Inflammation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1996.tb00145.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.729104"},{"key":"e_1_2_10_4_1","first-page":"345","article-title":"Endocrinological disorders and inflammatory skin diseases during COVID\u201019 outbreak: a review of the literature","volume":"45","author":"Marasca C","year":"2020","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2019.09.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.053"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-022-02432-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19286"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18473"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.08.056"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000478043"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18702"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16380"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12911"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_995_21"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01088.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.861241"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32834121b1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010076"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.09.014"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5945"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012489"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18095038"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.06.038"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15050"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443878"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15748"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210901"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.047"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081781"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2021.03.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp573"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2487"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.496"},{"key":"e_1_2_10_35_1","unstructured":"GuZ.ComplexHeatmap: Making Complex Heatmaps. R package version 1.6.02015.https:\/\/githubcom\/jokergoo\/ComplexHeatmap"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbr041"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5MB00663E"},{"key":"e_1_2_10_38_1","unstructured":"CarlsonM.M Carlson. org. hs. eg. db: Genome wide annotation for human. r package version 3.8.2.2019.2019."},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02965"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00087005"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0323"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.676241"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17578"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-00406-3"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R900011200"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-1028"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018126"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16409"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.10.015"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920049117"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21625"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00672-4"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01745"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66630-5"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008104"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm10030100"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2019.06.011"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911410223"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-021-00469-0"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13931"},{"key":"e_1_2_10_61_1","article-title":"Comparing the role of the p53 gene and Telomerase enzyme in 'Accelerated aging due to Cancer': a literature review","volume":"12","author":"Dhalla PS","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2013"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2010.02.006"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15319"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202101154"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12989"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031693"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3262047430"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00128"},{"key":"e_1_2_10_70_1","first-page":"10","article-title":"The PI3K\/Akt pathway: emerging roles in skin homeostasis and a Group of non\u2010malignant skin disorders","volume":"10","author":"Teng Y","year":"2021","journal-title":"Cell"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100702"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01267"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754211024157"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.08.006"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.08.001"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.19586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T05:15:26Z","timestamp":1725340526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.19586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/jdv.19586"],"URL":"https:\/\/doi.org\/10.1111\/jdv.19586","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,6]]},"assertion":[{"value":"2023-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}