{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:26:39Z","timestamp":1792761999331,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic inducible urticaria (CIndU) is a subtype of chronic urticaria (CU) which require specific physical or non\u2010physical triggers to occur. They may be isolated or may coexist with chronic spontaneous urticaria (CSU). Despite their frequent appearance in dermatology clinics, there is scarce information on the distinguishing features among the most common subtypes of CIndU as well as isolated CIndU versus CSU plus CIndU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare clinical and laboratory characteristics, and comorbid conditions among the most common CIndU types and isolated CIndU versus CSU plus CIndU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed CIndU patients and compared patients' demographic, clinical and laboratory characteristics across isolated CIndU, CSU plus CIndU, symptomatic dermographism (SD), cold urticaria (ColdU) and cholinergic urticaria (ChoU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 423 patients (~70% isolated CIndU, ~30% CSU plus CIndU, ~5% mixed CIndU subtypes) were included in the study. The most frequent CIndU subtypes were SD (68.6%; 290\/423), ColdU (11.4%; 48\/423) and ChoU (10.9%; 46\/423). Isolated CIndU patients were younger than CSU plus CIndU (33.74\u2009\u00b1\u200912.72 vs. 37.06\u2009\u00b1\u200911.84, <jats:italic>p<\/jats:italic>\u2009=\u20090.010). Angioedema, emergency referrals, need for systemic steroids, comorbid systemic disorders were more frequent and baseline urticaria control test scores were lower in CSU plus CIndU patients (vs. CIndU, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.008, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.031, <jats:italic>p<\/jats:italic>\u2009=\u20090.036, respectively). Among CIndU subtypes, ChoU patients were younger (24.9\u2009\u00b1\u200912.2 vs. 34.47\u2009\u00b1\u200912.12 vs. 31.38\u2009\u00b1\u200914.95; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and had male predominance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) while SD patients had no angioedema (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and had higher frequency of increased total IgE levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Isolated CIndU and CSU plus CIndU seems to be different endotypes of CU where CSU plus CIndU presents a more severe and refractory course. There are distinctive features of each CIndU subtype. These suggest involvement of different pathomechanistic pathways in these subtypes that need to be clarified in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19637","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:26:55Z","timestamp":1700785615000},"page":"513-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A comparative analysis of chronic inducible urticaria in 423 patients: Clinical and laboratory features and comorbid conditions"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-6035","authenticated-orcid":false,"given":"S.","family":"Ornek\u00a0Ozdemir","sequence":"first","affiliation":[{"name":"Department of Dermatology, Diskapi Yildirim Beyazit Training and Research Hospital Health Sciences University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9124-5817","authenticated-orcid":false,"given":"P.","family":"Kuteyla\u00a0Can","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bahcesehir University Faculty of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9596-2955","authenticated-orcid":false,"given":"E. N.","family":"Degirmentepe","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Private Practice  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-1067","authenticated-orcid":false,"given":"K.","family":"Cure","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Private Practice  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1395-5960","authenticated-orcid":false,"given":"R.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Prof Dr Cemil Tascioglu City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2801-0959","authenticated-orcid":false,"given":"E.","family":"Kocaturk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Koc University School of Medicine  Istanbul Turkey"},{"name":"Institute of Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Allergology and Immunology Fraunhofer Institute for Translational Medicine and Pharmacology ITMP  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15090"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12884"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20892"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.03.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13878"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2004.01.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.09.029"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2941"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2018.11.007"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20165071"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12901"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17724"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.31744\/einstein_journal\/2020AO5175"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2019.3674"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2019.84594"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00389-z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.02.283"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17385"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02496.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14674"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15194"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12117"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19425"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12661"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03489.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.901851"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2023.05.003"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.1008145"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13949"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14210"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-019-0278-3"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2019.100097"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.07.006"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2020.100101"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087491"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.050"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014794"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336572"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.00025.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.042"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.07.043"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507218"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12462239"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126782"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-020-00324-z"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.19637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T11:37:56Z","timestamp":1708947476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.19637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/jdv.19637"],"URL":"https:\/\/doi.org\/10.1111\/jdv.19637","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,22]]},"assertion":[{"value":"2023-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}