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However, there is limited information regarding intrinsic brain activity and cognitive function in patients with psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aim to assess alterations of intrinsic brain activity and its association with cognitive function in patients with psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 222 patients with psoriasis aged 18\u201370\u2009years and 144 age and gender\u2010matched healthy controls (HCs) were enrolled into this study. All subjects underwent brain resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) and neuropsychological testing. The rs\u2010fMRI data were analysed for both intrinsic brain activity as indicated by amplitude of low\u2010frequency fluctuation (ALFF) and seed\u2010based functional connectivity (FC). Correlative analysis of brain activity with cognitive assessment was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the HCs, patients with psoriasis had worse cognitive performance in the Trail Making Test, Digit Span Test and Stroop Color\u2010Word Test (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Patients with psoriasis showed decreased ALFF in the left superior frontal gyrus, the left medial superior frontal gyrus and the right precuneus gyrus; as well as enhanced ALFF in the left paracentral lobule (<jats:italic>p<\/jats:italic><jats:sub>FWE<\/jats:sub>\u2009&lt;\u20090.05). Significant correlations were noted between the altered ALFF in the four brain regions and cognitive assessment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, patients with psoriasis had increased FC between the four brain regions with altered ALFF (seeds) and the left prefrontal gyrus, the left anterior cingulate gyrus, left superior parietal lobule and default mode network (DMN) regions such as the right precuneus gyrus, left inferior parietal lobule, right angular gyrus and bilateral inferior temporal gyrus (<jats:italic>p<\/jats:italic><jats:sub>FWE<\/jats:sub>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with psoriasis had altered brain activity and connectivity in the key brain areas within the DMN\u2013prefrontal circuit. These brain changes may be the underlying neural correlates for cognitive functioning in patients with psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19685","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T04:24:27Z","timestamp":1702009467000},"page":"557-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Altered brain activity and cognitive impairment in patients with psoriasis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-1981","authenticated-orcid":false,"given":"Xiaoping","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Radiology, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Xiangya Hospital  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric 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