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DC values of the left superior frontal gyrus (LSFG) increased in AD participants and exhibited a negative correlation with the SCORAD score (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.561, <jats:italic>p<\/jats:italic>\u2009=\u20090.012) compared with HC. In the FC analysis with LSFG as the seed, FC values of several sensory and motor regions increased in AD participants, highly overlapping with the anatomical distribution of the inferior fronto\u2010occipital fascicle (IFOF). AD participants with severe pruritus exhibited lower levels of DC (<jats:italic>T<\/jats:italic>\u2009=\u2009\u22122.316, <jats:italic>p<\/jats:italic>\u2009=\u20090.033) and FC between the LSFG and left insula (<jats:italic>T<\/jats:italic>\u2009=\u2009\u22122.203, <jats:italic>p<\/jats:italic>\u2009=\u20090.042) than those with mild\u2010to\u2010 moderate pruritus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>LSFG was involved in pruritus regulation in AD by forming a high\u2010order sensorimotor circuit through the IFOF, a white matter fascicle that proved to provide multimodal integration in motor control and sensory information processing. These results offer more mechanism\u2010guided treatment targets for severe pruritus in AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19691","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T07:42:32Z","timestamp":1702107752000},"page":"873-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Higher\u2010order sensorimotor circuit of the whole\u2010brain functional network involved in pruritus regulation in atopic dermatitis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6571-7024","authenticated-orcid":false,"given":"Haishan","family":"Wu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Dai","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyi","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qin","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolun","family":"Wang","sequence":"additional","affiliation":[{"name":"Scientific Research Program of Hunan Provincial Health Commission, Department of Radiology, Clinical Research Center for Medical Imaging in Hunan Province The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyue","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11040438"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt158"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08281.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-017-0044-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.08.010"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000199"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03729.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00904.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02703.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.05.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02328.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2007.12.003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13305"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.12.002"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.223"},{"key":"e_1_2_11_17_1","volume-title":"Itch: mechanisms and treatment. 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