{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:11:28Z","timestamp":1791720688390,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a disease that often requires prolonged systemic treatment. It is important to determine the safety of available therapies. There is currently little insight into sex\u2010specific differences in the safety of systemic psoriasis therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the real\u2010world, long\u2010term safety of systemic psoriasis therapies with sex stratification in drug\u2010related adverse events (ADRs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten\u2010year data from adults with moderate\u2010to\u2010severe psoriasis requiring systemic treatment (conventional systemic therapies [CST], biologics) were obtained from the Swiss psoriasis registry (SDNTT). ADRs were categorized according to the international terminology Medical Dictionary for Regulatory Activities (MedDRA). Safety was assessed by calculating event rates per 100 patient\u2010years (PY). We used descriptive statistics for patient and disease characteristics, and binomial and <jats:italic>t<\/jats:italic>\u2010tests to compare treatment groups and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 791 patients (290 females) were included with a mean age of 46\u2009years. 358 (45%) received CSTs and 433 (55%) biologics; both groups had similar baseline characteristics except for more joint involvement in patients using biologics (26.86% vs. 14.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). CSTs were associated with a 2.2\u2010fold higher ADR rate (40.43\/100 PY vs. 18.22\/100 PY, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and an 8.0\u2010fold higher drug\u2010related discontinuation rate than biologics (0.16\/PY vs. 0.02\/PY, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Trends showed non\u2010significant higher serious adverse event rates per 100 PY for biologics (8.19, CI 6.87\u20139.68) compared to CSTs (7.08, CI 5.39\u20139.13) (<jats:italic>p<\/jats:italic>\u2009=\u20090.3922). Sex stratification revealed a significantly higher overall ADR rate for all treatments in females (1.8\u2010fold for CSTs [57.30\/100 PY vs. 31.69\/100 PY] and 2.0\u2010fold for biologics [27.36\/100 PY vs. 13.9\/100 PY], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and drug\u2010related discontinuation rates for most CSTs in females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Females were associated with a significantly higher rate of ADRs and drug\u2010related discontinuation rates. Sex stratification should be taken into consideration when designing studies in the patient\u2010tailored management of psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19730","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T23:49:25Z","timestamp":1702424965000},"page":"719-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sex differences in adverse events from systemic treatments for psoriasis: A decade of insights from the Swiss Psoriasis Registry (SDNTT)"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9263-8675","authenticated-orcid":false,"given":"Fabio","family":"Verardi","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara 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