{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:02:19Z","timestamp":1779307339719,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Augusto Bonome (1857\u20131922), professor at the University of Padua until 1922, was involved in a study about a particular kind of pulmonary leprosy, being the first to testify the lepromatous alterations also in the deepest parts of the respiratory tract, even though the same Gerhard Hansen (1841\u20131912) had denied the possibility that lungs could host Mycobacterium leprae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>It is necessary to reevaluate the research done by Bonome to also demonstrate how it can still be relevant today in further comprehension of leprosy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bonome's advances in leprosy studies are testified by some specimens from the Morgagni Museum of Pathological Anatomy of the University of Padua. Among the specimens, there is a peculiar case of advanced tuberous leprosy in an adolescent, who died in 1908, of which the face, the larynx, the hands and genitals are still preserved today in the Museum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Through autoptic and histological analysis of this specimen, Bonome succeeded in identifying a peculiar case of bone toxoid\u2010infectious dystrophy besides characteristic leprous laryngitis, which caused the death of the young leprosy patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results confirmed the innovative research carried on by Bonome during his medical career, being among the first to offer an important contribution to improving and revolutionary knowledge on leprosy which could still be useful today.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19733","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T23:47:58Z","timestamp":1702424878000},"page":"1246-1250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Augusto Bonome and his revolutionary studies on leprosy in the early 20th century"],"prefix":"10.1111","volume":"38","author":[{"given":"F.","family":"Valle","sequence":"first","affiliation":[{"name":"Department of Women's and Child's Health University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1553-2494","authenticated-orcid":false,"given":"G.","family":"Magno","sequence":"additional","affiliation":[{"name":"Morgagni Museum of Human Anatomy \u2013 University Museums Centre CAM, University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zanatta","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic Vascular Sciences and Public Health \u2013 University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20113"},{"issue":"37","key":"e_1_2_10_3_1","first-page":"409","article-title":"Global leprosy (Hansen disease) update, 2022: new paradigm \u2013 control to elimination","volume":"98","author":"World Health Organization","year":"2023","journal-title":"Wkly Epidemiol Rec"},{"issue":"4","key":"e_1_2_10_4_1","first-page":"1","article-title":"Unders\u00f8gelser Ang\u00e5ende Spedalskhedens \u00c5rsager","volume":"9","author":"Hansen GA","year":"1874","journal-title":"Nor Mag Laegevidenskaben"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"255","article-title":"Classification of leprosy according to immunity. 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