{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:57:20Z","timestamp":1784926640059,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI01583"],"award-info":[{"award-number":["PI01583"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prediction of the response to a biological treatment in psoriasis patients would allow efficient treatment allocation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify polymorphisms associated with secukinumab response in psoriasis patients in a daily practice setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 180 SNPs in patients with moderate\u2010to\u2010severe plaque psoriasis recruited from 15 Spanish hospitals. Treatment effectiveness was evaluated by absolute PASI \u22643 and \u22641 at 6 and 12\u2009months. Individuals were genotyped using a custom Taqman array. Multiple logistic regression models were generated. Sensitivity, specificity and area under the curve (AUC) were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 173 patients were studied at 6\u2009months, (67% achieved absolute PASI\u2009\u2264\u20093 and 65% PASI\u2009\u2264\u20091) and 162 at 12\u2009months (75% achieved absolute PASI\u2009\u2264\u20093 and 64% PASI\u2009\u2264\u20091). Multivariable analysis showed the association of different sets of SNPs with the response to secukinumab. The model of absolute PASI\u22643 at 6\u2009months showed best values of sensitivity and specificity. Four SNPs were associated with the capability of achieving absolute PASI\u2009\u2264\u20093 at 6\u2009months. rs1801274 (<jats:italic>FCGR2A<\/jats:italic>), rs2431697 (<jats:italic>miR\u2010146a<\/jats:italic>) and rs10484554 (<jats:italic>HLCw6<\/jats:italic>) were identified as risk factors for failure to achieve absolute PASI\u22643, while rs1051738 (<jats:italic>PDE4A)<\/jats:italic> was protective. AUC including these genotypes, weight of patients and history of biological therapy was 0.88 (95% CI 0.83\u20130.94), with a sensitivity of 48.6% and specificity of 95.7% to discriminate between both phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have identified a series of polymorphisms associated with the response to secukinumab capable of predicting the potential response\/non\u2010response to this drug in patients with plaque psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19782","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T17:32:57Z","timestamp":1703784777000},"page":"1783-1790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacogenetic biomarkers for secukinumab response in psoriasis patients in real\u2010life clinical practice"],"prefix":"10.1111","volume":"38","author":[{"given":"E.","family":"Mu\u00f1oz\u2010Aceituno","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario de la Princesa, Instituto de Investigaci\u00f3n Sanitaria La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4307-5016","authenticated-orcid":false,"given":"B.","family":"Butr\u00f3n\u2010Bris","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de la Princesa, Instituto de Investigaci\u00f3n Sanitaria La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-5165","authenticated-orcid":false,"given":"M. C.","family":"Ovejero\u2010Benito","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas y de la Salud, Facultad de Farmacia Universidad San Pablo\u2010CEU, CEU, CEU Universities Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-7464","authenticated-orcid":false,"given":"A.","family":"Sahuquillo\u2010Torralba","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario y Polit\u00e9cnico La Fe, Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Baniandr\u00e9s\u00a0Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Herrera\u2010Acosta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Virgen de la Victoria  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4604-0724","authenticated-orcid":false,"given":"R.","family":"Rivera\u2010Diaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ferran","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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