{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:21:47Z","timestamp":1792182107734,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary cutaneous B\u2010cell lymphomas (CBCL) are a group of rare malignant skin diseases that represent approximately 20%\u201330% of all primary cutaneous lymphomas (PCL). Previous studies revealed impaired health\u2010related quality of life (HRQoL) in patients diagnosed with primary cutaneous T\u2010cell lymphoma (CTCL). Currently, only small\u2010sized studies investigated HRQoL in CBCL patients and lacked detailed analysis of respective subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to investigate HRQoL in CBCL patients to identify independent factors of HRQoL impairment in CBCL patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred CBCL patients were recruited from eight German PCL centres in this multicentric, cross\u2010sectional study from 2021 to 2022. The patients completed the dermatologic HRQoL questionnaire Skindex\u201029 and an investigator\u2010designed \u2018CBCL\u2010Questionnaire\u2019 with additional questions on HRQoL and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Skindex\u201029 revealed that HRQoL in CBCL patients is impaired on a mild to moderate level. The multiple regression analysis identified parameters like worries about dying, feeling prejudiced\/discriminated and impairment of daily activities to be independently associated with impairment of HRQoL. Highest scores for HRQoL impairment were found in patients with primary cutaneous follicle centre lymphoma while on rituximab treatment and in patients with primary cutaneous marginal zone lymphoma while on watchful waiting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HRQoL is impaired in CBCL patients, even though, in the face of indolent disease course and favourable prognosis in the majority of cases. Of note, our investigator\u2010designed tool identified worries about dying, feeling prejudiced\/discriminated, and the type of treatment to have a negative impact on patients' HRQoL. Our study highlights the importance of a thorough patient\u2013doctor communication to capture overall disease burden because generic HRQoL tools might lack of disease\u2010specific items.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19799","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T07:18:45Z","timestamp":1706339925000},"page":"954-966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Health\u2010related quality of life and its influencing factors in patients with primary cutaneous B\u2010cell lymphomas: A multicentric study in 100 patients"],"prefix":"10.1111","volume":"38","author":[{"given":"A. E. 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