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The drug has received Food and Drug administration authorisation for mycosis fungoides and S\u00e9zary syndrome following failure of at least one previous course of systemic therapy and now is available in Europe. One of the most common treatment\u2010related side effects observed has been the mogamulizumab\u2010associated rash (MAR), which affects up to a quarter of patients and is the most frequent adverse event leading to drug discontinuation. The aim of this study is to perform a systematic review of the literature on patients diagnosed with MAR and other mogamulizumab\u2010related cutaneous events to describe the clinical and histological characteristics, the management in clinical practice and to assess whether these events have prognostic implications. In total, 2073 records were initially identified through a literature search, 843 of which were duplicates. After screening for eligibility and inclusion criteria, 49 articles reporting mogamulizumab\u2010associated cutaneous events were included. Totally, 1516 patients were retrieved, with a slight male prevalence as for the available data (639 males and 570 females, i.e. 52.9% vs. 47.1%). Regarding the reported clinicopathological findings of the cutaneous reactions, the five most common patterns were spongiotic\/psoriasiform dermatitis (22%), eruptions characterized by the presence of papules and\/or plaques (16.1%), cutaneous granulomatosis (11.4%), morbilliform or erythrodermic dermatitis (9.4%) and photodermatitis (7.1%). Our results highlight how the majority of the reported cutaneous adverse events on mogamulizumab are of mild\u2010to\u2010moderate entity and generally manageable in clinical practice, though prompt recognition is essential and case\u2010by\u2010case assessment should be recommended. Future research will need to focus on the MAR prognostic implications and to identify genomic and molecular markers for a more rapid and accurate diagnosis.<\/jats:p>","DOI":"10.1111\/jdv.19801","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T07:28:10Z","timestamp":1706340490000},"page":"1738-1748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Clinicopathological definition, management and prognostic value of mogamulizumab\u2010associated rash and other cutaneous events: A systematic review"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-2370","authenticated-orcid":false,"given":"G.","family":"Avallone","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Dermatology Clinic University of Turin  Turin Italy"},{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-5506","authenticated-orcid":false,"given":"G.","family":"Roccuzzo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Dermatology Clinic University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pileri","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS of Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Dermatology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES) University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Agostinelli","sequence":"additional","affiliation":[{"name":"Hematopathology Unit, Department of Experimental, Diagnostic and Specialty Medicine University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-849X","authenticated-orcid":false,"given":"C. 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