{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:14:08Z","timestamp":1784042048491,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002001"],"award-info":[{"award-number":["UL1 TR002001"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["53234087"],"award-info":[{"award-number":["53234087"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atopic dermatitis (AD) is a chronic skin disease that affects 20% of children worldwide and is associated with low patient\u2010reported quality of life (QoL). Crisaborole (CRIS) and tacrolimus 0.03% (TAC) are Food and Drug Administration (FDA)\u2010approved topical treatments for mild to moderate AD with similar clinical efficacy. Utilization of patient\u2010reported outcomes (PROs) may provide meaningful data on the impact of AD treatments on patients and caregivers. This study used PROs to monitor the impact of crisaborole (CRIS) and tacrolimus 0.03% (TAC) on children with mild\/moderate atopic dermatitis (AD) and caregiver burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This open\u2010label study randomized 47 child\u2010caregiver dyads to CRIS or TAC for 12\u2009weeks. Disease severity, child quality of life (QoL), itch, pain interference, anxiety, depression, sleep, caregiver burden and caregiver QoL were assessed at baseline, 6 and 12\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 36 dyads completed the study. Children (mean age\u2009=\u20098.0\u2009\u00b1\u20093.9\u2009years) had mild baseline AD and were diverse by race (39% white; 36% Black) and gender (53% males). Caregivers were mostly female (78%; mean age\u2009=\u200937\u2009\u00b1\u20097.6\u2009years). Both arms improved disease severity (Eczema Area and Severity Index) from baseline to 12\u2009weeks (CRIS\u2009=\u2009\u22122.4 vs. TAC\u2009=\u2009\u22121.9). Within\u2010arm analyses comparing baseline to 12\u2009weeks revealed TAC, but not CRIS, improved all child and caregiver PROs except sleep (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrated that topical treatment for 12\u2009weeks was more beneficial than 6\u2009weeks, with TAC improving more PROs than CRIS. Future trials should implement PROs to fully understand the impact of AD treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19807","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T09:34:20Z","timestamp":1707989660000},"page":"1364-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Improved patient\u2010 and caregiver\u2010reported outcomes distinguish tacrolimus 0.03% from crisaborole in children with atopic dermatitis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0592-7820","authenticated-orcid":false,"given":"Julie","family":"Ryan Wolf","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics 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