{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T21:00:57Z","timestamp":1771189257942,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100023331","name":"LEO Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite that brodalumab's efficacy and safety have been assessed in randomized clinical trials, real\u2010life data remain scarce. BrIDGE was an observational, prospective, single\u2010cohort, multicentre study that recruited patients with moderate\u2010to severe plaque psoriasis in Greece.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The primary objective was to assess the proportion of patients who achieved Psoriasis Area and Severity Index (PASI)100 after 24\u2009weeks. Other endpoints included: the maintenance of PASI90\/100 through to 104\u2009weeks, the short\u2010term response [PASI75\/90\/100 and static Physician's Global Assessment (sPGA) 0\/1] to brodalumab at 12\u201316\u2009weeks and time to complete clearance. Moreover, we explored the change in quality of life [Dermatology Life Quality Index (DLQI) 0\/1] and adherence to brodalumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred patients who were initiating treatment with or switching to brodalumab, were recruited. Analyses were conducted using the as observed data and three imputation approaches were also applied for the missing data (last observation carried forward, \u2018worst case\u2019 and \u2018best case\u2019 scenario). Continuous variables were reported using summary statistics, whereas categorical variables were reported in frequency tables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the \u2018as observed data\u2019, 42.0% of patients achieved PASI100 at Week 24 after 25.9\u2009\u00b1\u20093.5\u2009weeks and 65% of patients attained PASI100 at Week 104. In total, 70.2%, 47.5% and 32.0% achieved PASI75\/90\/100, respectively, whereas 72.6% of patients achieved sPGA 0\/1, at Weeks 12\u201316. With respect to sPGA status 82.8%, 89.2% and 92.5% of patients achieved sPGA 0\/1 at Weeks 24, 52 and 104, respectively. The time to achieve PASI100 at Weeks 12\u201316 was 13.7\u2009\u00b1\u20091.3, 52.1\u2009\u00b1\u20093.4\u2009weeks at Week 52 and 105.5\u2009\u00b1\u20094.8\u2009weeks at Week 104. Mean DLQI and Psoriasis Symptom Inventory (PSI) scores decreased by 11.4\u2009\u00b1\u20097.0 and 15.4\u2009\u00b1\u20096.5 points from baseline to Week 104, respectively. Adherence to treatment was equal to 98.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Brodalumab confers rapid and durable responses, as well as improvements in the quality of life of moderate\u2010to\u2010severe psoriasis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19816","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T11:25:12Z","timestamp":1706959512000},"page":"1121-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>Real\u2010world<\/scp> data on the effectiveness of brodalumab in patients with moderate\u2010to severe plaque psoriasis in the Greek clinical setting (the <scp>BrIDGE<\/scp> study)"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4841-7484","authenticated-orcid":false,"given":"Dimitrios","family":"Rigopoulos","sequence":"first","affiliation":[{"name":"1st Department of Dermatology\u2010Venereology University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-5085","authenticated-orcid":false,"given":"Eleftheria","family":"Tampouratzi","sequence":"additional","affiliation":[{"name":"Dermatological Department Tzaneio General Hospital  Piraeus Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos","family":"Angelakopoulos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Athens Naval Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9255-8196","authenticated-orcid":false,"given":"Zoe","family":"Apalla","sequence":"additional","affiliation":[{"name":"2nd Dermatology Department Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Barkis","sequence":"additional","affiliation":[{"name":"Private Physician  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical School, General University Hospital University of Patras  Patras Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-7118","authenticated-orcid":false,"given":"Florentina","family":"Delli","sequence":"additional","affiliation":[{"name":"State Dermatology Department Hippokratio General Hospital of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Drosos","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Xanthi  Xanthi 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Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8634-102X","authenticated-orcid":false,"given":"Evangelia","family":"Papadavid","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology Attikon University Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markos","family":"Papakonstantis","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology 401 General Military Hospital of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeliki\u2010Viktoria","family":"Roussaki\u2010Schulze","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University General Hospital Larissa University of Thessaly  Larissa 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