{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:49Z","timestamp":1791895609465,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"S7","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is a common chronic inflammatory disorder of the pilosebaceous unit, characterized by papules, pustules and\/or nodules manifesting primarily on the face and\/or upper back that can leave scars, post\u2010inflammatory hyperpigmentation (PIH) and erythema (PIE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the anti\u2010inflammatory properties of a protein\u2010free sap extruded from Rhealba\u00ae oat plantlets and a <jats:italic>Garcinia mangostana<\/jats:italic> extract on <jats:italic>Cutibacterium acnes<\/jats:italic>\u2010induced inflammation in\u00a0vitro and assess the tolerability and efficacy of a dermocosmetic product containing these actives in subjects with mild\u2010to\u2010moderate acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Monocyte\u2010derived dendritic cells (Mo\u2010DCs) from acne patients were stimulated with a planktonic culture of <jats:italic>C. acnes<\/jats:italic> and cytokine production was evaluated before and after addition of the test extracts by RT\u2010PCR and ELISA. The clinical study was conducted in subjects with mild\u2010to\u2010moderate acne who applied the product to their face and upper back twice\u2010daily for 2\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Cutibacterium acnes<\/jats:italic>\u2010induced IL\u20106, IL\u201012p40, IL\u201010 and TNF\u03b1 synthesis was reduced by the addition of the <jats:italic>Garcinia mangostana<\/jats:italic> extract and oat sap in\u00a0vitro. The clinical study included 54 subjects. The 2\u2010month, twice\u2010daily application of the test product to the whole face and acne\u2010affected areas on the upper back was well tolerated. It led to significant decreases in the number of retentional (\u221221% for 69% of subjects at D57) and inflammatory (\u221235% for 79% of subjects at D57) acne lesions, as well as a decrease in Global Acne Evaluation severity scores (2.5 at D1, 2.2 at D29 and 2.1 at D57). The dermatologist also rated the product as effective or very effective in most subjects with PIE (82%; <jats:italic>n<\/jats:italic>\u2009=\u200933\/40) and PIH (70%; <jats:italic>n<\/jats:italic>\u2009=\u20098\/11) at D57.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The actives demonstrated anti\u2010inflammatory effects in\u00a0vitro, and the dermocosmetic product showed good clinical efficacy and tolerability in subjects with mild\u2010to\u2010moderate acne, supporting the use of this product in acne management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19876","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T09:09:13Z","timestamp":1721898553000},"page":"12-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A dermocosmetic product containing the sap of oat plantlets and <i>Garcinia mangostana<\/i> extract improves the clinical signs of acne"],"prefix":"10.1111","volume":"38","author":[{"given":"F.","family":"Carballido","sequence":"first","affiliation":[{"name":"Laboratoires A\u2010Derma, Pierre Fabre Dermo\u2010Cosm\u00e9tique  Lavaur France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Philippe","sequence":"additional","affiliation":[{"name":"Pierre Fabre Dermo\u2010Cosm\u00e9tique, Research &amp; 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