{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:44:11Z","timestamp":1792205051611,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["459731775"],"award-info":[{"award-number":["459731775"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1597\u2010499552394"],"award-info":[{"award-number":["SFB 1597\u2010499552394"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011960","name":"Debra International","doi-asserted-by":"publisher","award":["Reimer\u20101"],"award-info":[{"award-number":["Reimer\u20101"]}],"id":[{"id":"10.13039\/501100011960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic inflammation is considered a major player in the pathogenesis of epidermolysis bullosa (EB), but its pattern has only been described in small heterogeneous cohorts. There is controversy if and how systemic inflammation should be therapeutically targeted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined serum proinflammatory, anti\u2010inflammatory, and itch related cytokines in a paediatric cohort of 29 patients with junctional and dystrophic EB. The cytokine that emerged as the most relevant was measured in a validation cohort of 42 patients during follow\u2010up visits over 2\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u20106 showed the most consistent and highest aberration dominating systemic inflammation. IL\u20106 correlated with wound body surface area (BSA) in both, finding and validation cohorts. Patients with less than 3% wound BSA had normal IL\u20106, while IL\u20106 levels significantly increased at more than 5% and 10% of wound BSA. TGF\u2010\u03b2 was only marginally elevated in patients with severe recessive dystrophic EB, while TNF\u2010\u03b1, IFN\u2010\u03b3 and IL\u20101\u03b2 varied inconsistently. Patients reporting itch showed elevations in type 2 immunity (IgE, TSLP, IL4 and\/or IL\u201031, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest a dominant skin barrier and wound healing inflammatory pattern in junctional and dystrophic EB that depends on the wound area and not on the EB type. In EB, itch mediators may be similar to other pruritic disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19898","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T13:42:12Z","timestamp":1708436532000},"page":"202-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<scp>IL<\/scp>\u20106 levels dominate the serum cytokine signature of severe epidermolysis bullosa: A prospective cohort study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3378-4476","authenticated-orcid":false,"given":"A.","family":"Reimer\u2010Taschenbrecker","sequence":"first","affiliation":[{"name":"Department of Dermatology, Medical Faculty and Medical Center University of Freiburg  Freiburg Germany"},{"name":"Department of Dermatology, Feinberg School of Medicine Northwestern University  Chicago Illinois 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