{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:41:51Z","timestamp":1787730111524,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are only a few clinical trials which address the treatment of acute urticaria (AU). Especially, the added value of systemic corticosteroids to antihistamines is unclear in treatment of severe AU. To review the existing evidence\u2010based approaches for AU treatment. A systematic electronic search was done in PubMed and Web of Science to retrieve all studies on the treatment of patients with AU. A descriptive synthesis was conducted based on the PRISMA statement. Quality assessment was independently performed by both reviewers (\u2018Cochrane risk\u2010of\u2010bias tool\u2019 for RCTs). Ten randomized controlled trials (RCTs) (<jats:italic>n<\/jats:italic>\u2009=\u2009857 participants) were included. Four studies assessed corticosteroid effectiveness added to antihistamines and six studies compared the efficacy of H<jats:sub>1<\/jats:sub> and\/ or H<jats:sub>2<\/jats:sub>\u2010antihistamines. The addition of corticosteroid (prednisone) to an antihistamine (levo)cetirizine did not improve symptoms of AU compared to antihistamine alone in two out of three RCTs. The combination of diphenhydramine (50\u2009mg, IV) and ranitidine (50\u2009mg, IV) or cimetidine (300\u2009mg, IV) was most efficient for relief of urticaria in two out of five studies. Most frequent adverse effects were sedation and drowsiness. Recent guidelines on urticaria treatment mainly focus on chronic urticaria rather than on AU. Moreover, only few, small RCTs provide evidence for the management of AU. Thus, the state\u2010of\u2010the\u2010art management of this frequent condition remains unclear. The addition of corticosteroids to an antihistamine as treatment for AU needs to be further investigated. Well\u2010designed, high\u2010quality interventional trials are needed to establish evidence\u2010based treatment guidelines for AU.<\/jats:p>","DOI":"10.1111\/jdv.19904","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T09:59:48Z","timestamp":1709200788000},"page":"2082-2092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment of acute urticaria: A systematic review"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-6450","authenticated-orcid":false,"given":"Fariza M. 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