{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:02:36Z","timestamp":1792594956014,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hyperpigmentation disorders are very frequent, affect the quality of life and may become a psychological burden for afflicted patients. Many anti\u2010pigmenting or depigmenting agents are available with various efficacy and almost no comparative data. 2\u2010mercaptonicotinoyl glycine (2\u2010MNG) was recently proposed as a viable candidate showing safe and effective results on hyperpigmentation control in\u00a0vitro and in\u00a0vivo<jats:italic>.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A Bayesian network meta\u2010analysis (BNMA) was conducted to map and rank the anti\u2010pigmenting and depigmenting efficacy of 2\u2010MNG 0.5% on UV daylight (UVDL)\u2010induced pigmentation together with 13 other reference molecules. A comparison in the kinetics of 2\u2010MNG 0.5% was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Fourteen studies were conducted, for each, on 15\u201330 women of skin phototype III in Shanghai, China and Paris, France. The products were applied on mini zone, in randomized and blinded protocol, on the back, 5\u2009days a week during 6\u2009weeks, at a dose of 4\u2009mg\/cm<jats:sup>2<\/jats:sup>. During the second week, volunteers were exposed under to varying minimum erythemal dose of UVDL during 4 consecutive days\u2014adapted to obtain a similar induction of skin pigmentation regardless of the population. Assessments were performed instrumentally using Chromameter\u00ae. Ascorbic acid 7% was used as a positive control for all experiments. A Bayesian network meta\u2010analysis was then established to map and follow the kinetics of 2\u2010MNG 0.5% performance with 13 reference molecules (glutathione 2%, kojic acid 1%, hydroquinone 4%, ascorbyl glucoside 2%, niacinamide 4%, etc.).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>2\u2010MNG 0.5% dominated the ranking at all time points with a significant high probability of strong efficacy against UVDL\u2010induced pigmentation. Ascorbic acid 7% ranks second after 4\u2009days of irradiations (D<jats:sub>12<\/jats:sub>) whereas hydroquinone 4% ranks second 1\u2009month after irradiations (D<jats:sub>40<\/jats:sub>). In the kinetics, 2\u2010MNG at 0.5% was effective as from the end of irradiations (D<jats:sub>12<\/jats:sub>) to the study endpoint (D<jats:sub>40<\/jats:sub>). This suggested an immediate and persistent efficacy across all timepoints evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The BNMA revealed a rapid and lasting efficacy of 2\u2010MNG 0.5% on the anti\u2010pigmenting and depigmenting phases of the clinical protocol. 2\u2010MNG 0.5% ranked first, with immediate and lasting effect compared to 13 other references. This study is the first allowing comparison between reference anti\u2010pigmenting and depigmenting agents and will help clinicians for proposing the most effective approach for their patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19910","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T07:05:06Z","timestamp":1709535906000},"page":"1566-1574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Bayesian network meta\u2010analysis of 14 molecules inhibiting <scp>UV<\/scp> daylight\u2010induced pigmentation"],"prefix":"10.1111","volume":"38","author":[{"given":"Benoit","family":"Muller","sequence":"first","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-9535","authenticated-orcid":false,"given":"Frederic","family":"Flament","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Jouni","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay\u2010sous\u2010Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Sextius","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay\u2010sous\u2010Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Tachon","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hequn","family":"Wang","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Qiu","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janney","family":"Qiu","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Amar","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Chevilly\u2010Laure France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Delaunay","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Chevilly\u2010Laure France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina G.","family":"Jablonski","sequence":"additional","affiliation":[{"name":"Department of Anthropology The Pennsylvania State University  University Park Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6570","authenticated-orcid":false,"given":"Thierry","family":"Passeron","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universit\u00e9 C\u00f4te d'Azur, CHU Nice  Nice France"},{"name":"Universit\u00e9 C\u00f4te d'Azur, INSERM  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12986"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2023.02.005"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200001050-00001"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19230"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.01.051"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14095"},{"issue":"2","key":"e_1_2_13_8_1","first-page":"3502","article-title":"Alpha arbutin as a skin lightening agent: a review","volume":"13","author":"Chandorkar N","year":"2021","journal-title":"Int J Pharma Res"},{"issue":"2","key":"e_1_2_13_9_1","article-title":"Are natural ingredients effective in the management of hyperpigmentation? 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