{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:49:26Z","timestamp":1782125366830,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is still limited clinical\u2010practice data on specific clinical and patch test features, as well as on allergen clusters in polysensitization (PS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the frequency, relevance, symptoms duration and risk factors in polysensitized patients and to assess possible allergen aggregation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective multicentric study (January 2019\u2013December 2022) conducted in setting of the Spanish Contact Dermatitis Register (REIDAC). Clinical and patch test data of polysensitized and oligosensitized patients were compared, and risk factors of PS were investigated with logistic multivariate regression. Unsupervised hierarchical clustering and network analysis were used to study allergen aggregation in PS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10,176 patients were analysed. PS was found in 844 (8.3%). Current relevance was significantly higher in polysensitized patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Risk factors for PS were atopic dermatitis (OR: 1.58, 95% CI: 1.24\u20132.02), age (\u226560\u2009years vs. \u226424\u2009years, OR: 1.75, 95% CI: 1.25\u20132.44) and some special locations (legs vs. face OR: 1.54, 95% CI: 1.05\u20132.25, hands vs. face OR: 1.46, 95% CI:1.15\u20131.85, arms vs. face OR: 1.49, 95% CI:1.01\u20132.20, trunk vs. face OR: 1.40, 95% CI:1.06\u20131.85). Cluster and network analyses revealed specific\u2010allergen clusters and significant associations, including allergens belonging to metals group, fragrances and botanicals group, topical drugs group, rubber allergens and biocides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study confirms that PS is structured by discernible patterns of specific\u2010allergen clusters and reinforces significant allergen associations in PS. Cross\u2010reactivity and\/or concomitant sensitization could explain the formation of allergen clusters in PS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19934","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T13:40:12Z","timestamp":1709041212000},"page":"126-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Polysensitization in the Spanish Contact Dermatitis Registry (<scp>REIDAC<\/scp>): A 2019\u20132022 prospective study with cluster and network analysis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-9780","authenticated-orcid":false,"given":"David","family":"Pesqu\u00e9","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona 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Javier","family":"Miquel\u2010Miquel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Arnau de Vilanova de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gonz\u00e1lez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Araba, Universidad del Pa\u00eds Vasco  Vitoria\u2010Gasteiz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Dr Balmis, ISABIAL  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"C\u00f3rdoba\u2010Guijarro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Fuenlabrada  Madrid 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