{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:08:26Z","timestamp":1790712506651,"version":"4.1.0"},"reference-count":167,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The interleukin (IL)\u20101 superfamily upregulates immune responses and maintains homeostasis between the innate and adaptive immune systems. Within the IL\u20101 superfamily, IL\u201036 plays a pivotal role in both innate and adaptive immune responses. Of the four IL\u201036 isoforms, three have agonist activity (IL\u201036\u03b1, IL\u201036\u03b2, IL\u201036\u03b3) and the fourth has antagonist activity (IL\u201036 receptor antagonist [IL\u201036Ra]). All IL\u201036 isoforms bind to the IL\u201036 receptor (IL\u201036R). Binding of IL\u201036\u03b1\/\u03b2\/\u03b3 to the IL\u201036R recruits the IL\u20101 receptor accessory protein (IL\u20101RAcP) and activates downstream signalling pathways mediated by nuclear transcription factor kappa B and mitogen\u2010activated protein kinase signalling pathways. Antagonist binding of IL\u201036Ra to IL\u201036R inhibits recruitment of IL\u20101RAcP, blocking downstream signalling pathways. Changes in the balance within the IL\u201036 cytokine family can lead to uncontrolled inflammatory responses throughout the body. As such, IL\u201036 has been implicated in numerous inflammatory diseases, notably a type of pustular psoriasis called generalized pustular psoriasis (GPP), a chronic, rare, potentially life\u2010threatening, multisystemic skin disease characterised by recurrent fever and extensive sterile pustules. In GPP, IL\u201036 is central to disease pathogenesis, and the prevention of IL\u201036\u2010mediated signalling can improve clinical outcomes. In this review, we summarize the literature describing the biological functions of the IL\u201036 pathway. We also consider the evidence for uncontrolled activation of the IL\u201036 pathway in a wide range of skin (e.g., plaque psoriasis, pustular psoriasis, hidradenitis suppurativa, acne, Netherton syndrome, atopic dermatitis and pyoderma gangrenosum), lung (e.g., idiopathic pulmonary fibrosis), gut (e.g., intestinal fibrosis, inflammatory bowel disease and Hirschsprung's disease), kidney (e.g., renal tubulointerstitial lesions) and infectious diseases caused by a variety of pathogens (e.g., COVID\u201019;\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    infections), as well as in cancer. We also consider how targeting the IL\u201036 signalling pathway could be used in treating inflammatory disease states.\n                  <\/jats:p>","DOI":"10.1111\/jdv.19935","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:35:04Z","timestamp":1716446104000},"page":"1910-1925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The role of interleukin\u201036 in health and disease states"],"prefix":"10.1111","volume":"38","author":[{"given":"Kazumitsu","family":"Sugiura","sequence":"first","affiliation":[{"name":"Department of Dermatology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School of Medicine Mie University  Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-9315","authenticated-orcid":false,"given":"Masashi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169479"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00840.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00364"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106151"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.01.005"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2022.01.006"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.14.10308"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1169"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01162"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.06.017"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13310"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02281-2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010022\u201002083\u2010z"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155887"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133318"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155897"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.033"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400117200"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00200"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13228"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016080840"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142035"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-439026"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.024"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.02.012"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646788"},{"key":"e_1_2_12_28_1","first-page":"967","article-title":"Polymorphisms in the promoters of MMP\u20102 and TIMP\u20102 genes in patients with acne vulgaris","volume":"6","author":"Yaykasli KO","year":"2013","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12761"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02532"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310374"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.808012"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108515"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.056"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400538"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.05.012"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301481"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.267922"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.234"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.072"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.010"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.08.444"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.082"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjw006"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121534109"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.754702"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12610"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0277-8"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI144336"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3RI1014-495R"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801377115"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/09680519030090030801"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2022.2116003"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2808"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.019"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00652-1"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13699"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.2165\/11586900-000000000-00000"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12070"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2019.1648209"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094344"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01764"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.11.024"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013068"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.490"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.038"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.230"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.288"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.06.618"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.04.005"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.06.020"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.07.001"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14171"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111563"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00504-0"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346572"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S180608"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14386"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10082094"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.651"},{"key":"e_1_2_12_81_1","article-title":"Hidradenitis suppurativa: a perspective on genetic factors involved in the disease","volume":"10","author":"Moltrasio C","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.162"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12966"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00847"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-017-1769-5"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16019"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14389"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19538"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14542"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128678"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.02.010"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.08.024"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.12.018"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143334"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.11.047"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/77811"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00699-8"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.673453"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01980"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.08.431"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15837"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14534"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00744.x"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155921"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2022.02.015"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01733-x"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.11.029"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.08.022"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.107"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.130"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.134"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718902115"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004484117"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501312"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2022.2084381"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.21"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-016-4011-1"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2013.03.001"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.07.054"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12629"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059066"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1004061529723"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-020-00867-x"},{"key":"e_1_2_12_124_1","article-title":"An overview of systemic lupus erythematosus (SLE) pathogenesis, classification, and management","volume":"14","author":"Ameer MA","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2021.1452"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.148"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113060"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-01076-6"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.051"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2762"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.05.087"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.662266"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S278335"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701796"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05363-4"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.07.034"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw152"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19476-x"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900169"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0640-1"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00583-18"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03909-4"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.07.014"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01803"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317706918"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101501"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0385-4"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12406"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45626-w"},{"key":"e_1_2_12_151_1","unstructured":"U.S. Food and Drug Administration.SPEVIGO (spesolimab) prescribing information.2022. Available from:https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/761244s000lbl.pdf. Accessed 3 Nov 2023."},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.601477"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2017.1353853"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.07.022"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15867"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.043"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1611-x"},{"key":"e_1_2_12_158_1","article-title":"Imsidolimab, an anti\u2010IL\u201036 receptor monoclonal antibody, in the treatment of generalized pustular psoriasis: results from a phase 2 trial","author":"Gudjonsson J","year":"2021","journal-title":"Eur Acad Dermatol Venereol"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155215"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.186"},{"key":"e_1_2_12_161_1","unstructured":"NCT03633396.A study to evaluate the efficacy and safety of imsidolimab (ANB019) in adults with palmoplantar pustulosis (POPLAR).2022. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT03633396. Accessed 3 Nov 2023."},{"key":"e_1_2_12_162_1","unstructured":"AnaptysBio Inc.AnaptysBio reports HARP phase 2 top\u2010line data of imsidolimab in moderate\u2010to\u2010severe hidradenitis suppurativa.2022. Available from:https:\/\/ir.anaptysbio.com\/news\u2010releases\/news\u2010release\u2010details\/anaptysbio\u2010reports\u2010harp\u2010phase\u20102\u2010top\u2010line\u2010data\u2010imsidolimab. Accessed 3 Nov 2023."},{"key":"e_1_2_12_163_1","unstructured":"NCT04762277.A study to test whether spesolimab helps people with a skin disease called hidradenitis suppurativa.2021. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04762277. Accessed 3 Nov 2023."},{"key":"e_1_2_12_164_1","unstructured":"NCT03482635.BI655130 (SPESOLIMAB) induction treatment in patients with moderate\u2010to\u2010severe ulcerative colitis.2021. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT03482635. Accessed 3 Nov 2023."},{"key":"e_1_2_12_165_1","unstructured":"NCT03123120.A study in patients with mild or moderate ulcerative colitis who take a TNF inhibitor. The study investigates whether bowel inflammation improves when patients take BI 655130 in addition to their current therapy. 2021. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT03123120. Accessed 3 Nov 2023."},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.02.056"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.055"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.19935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:51:43Z","timestamp":1739249503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.19935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":167,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/jdv.19935"],"URL":"https:\/\/doi.org\/10.1111\/jdv.19935","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]},"assertion":[{"value":"2023-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}