{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:55:43Z","timestamp":1792076143552,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","award":["R310\u20102018\u20103711"],"award-info":[{"award-number":["R310\u20102018\u20103711"]}],"id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF170C0029698"],"award-info":[{"award-number":["NNF170C0029698"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Understanding the role of calcitonin gene\u2010related peptide (CGRP) in the pathogenesis of rosacea might provide new therapeutic avenues for individuals with this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare plasma levels of CGRP between individuals with rosacea and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional case\u2013control study conducted in Copenhagen, Denmark, we collected blood samples from the antecubital vein from adults with rosacea and from healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 123 individuals with rosacea and 68 healthy controls. After adjusting for age and sex, plasma levels of CGRP were significantly higher in individuals with rosacea (mean, 95% confidence interval: 140.21\u2009pmol\/L, 128.50\u2013151.92\u2009pmol\/L), compared with controls (110.77\u2009pmol\/L, 99.91\u2013120.14\u2009pmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Plasma levels of CGRP were not affected by age, sex, BMI, concomitant migraine, rosacea sub\u2010 or phenotype, concomitant disease or current treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Participants were not age\u2010, sex\u2010 and BMI\u2010matched.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Elevated plasma levels of CGRP in individuals with rosacea suggest a role of CGRP in the pathogenesis of rosacea. Targeting CGRP signalling might hold therapeutic promise in people affected by this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinicaltrials.gov listing<\/jats:title><jats:p>NCT03872050<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19954","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T09:18:45Z","timestamp":1711963125000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Elevated plasma levels of calcitonin gene\u2010related peptide in individuals with rosacea: A cross\u2010sectional case\u2013control study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-0796","authenticated-orcid":false,"given":"Nita K. F.","family":"Wienholtz","sequence":"first","affiliation":[{"name":"Department of Neurology, Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Dermatology, Bispebjerg and Frederiksberg Copenhagen University  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper E.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Ashina","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Brain and Spinal Cord Injury Copenhagen University Hospital\u2010Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine 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