{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:11:24Z","timestamp":1789186284453,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1130615"],"award-info":[{"award-number":["1130615"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1160858"],"award-info":[{"award-number":["1160858"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1201568"],"award-info":[{"award-number":["1201568"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D (VD) deficiency is common among patients with atopic dermatitis (AD) and often associated with severity. However, randomized trials of VD supplementation in AD have had equivocal results, and there is little information regarding the effect of VD supplementation on type 2 immunity in AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the efficacy of VD supplementation to decrease severity of AD and to alter type 2 immunity biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a randomized, double\u2010blind, placebo\u2010controlled trial. We randomly assigned 101 children with AD to weekly oral vitamin D3 (VD3) or placebo for 6\u2009weeks. The primary outcome was the change in the Severity Scoring of AD (SCORAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age of subjects was 6.3\u2009\u00b1\u20094.0\u2009years, and baseline SCORAD was 32\u2009\u00b1\u200929. At baseline, 57% of children were VD deficient, with no difference between groups. Change in 25(OH)D was significantly greater with VD3 than placebo (+43.4\u2009\u00b1\u200934.5\u2009nmol\/L vs. +2.3\u2009\u00b1\u200921.2\u2009nmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). SCORAD change at 6\u2009weeks was not different between VD and placebo (\u22125.3\u2009\u00b1\u200911.6 vs. \u22125.5\u2009\u00b1\u20099.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.91). There were no significant between\u2010group differences in change of eosinophil counts, total IgE, Staphylococcal enterotoxin specific IgE, CCL17, CCL22, CCL27, LL\u201037 or Staphylococcus aureus lesional skin colonization. Vitamin D receptor (\n                      <jats:italic>VDR<\/jats:italic>\n                      ) gene single nucleotide polymorphisms\n                      <jats:italic>FokI<\/jats:italic>\n                      ,\n                      <jats:italic>ApaI<\/jats:italic>\n                      and\n                      <jats:italic>TaqI<\/jats:italic>\n                      did not modify subjects' response to VD supplementation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among children with AD, weekly VD supplementation improved VD status but did not modify AD severity or type 2 immunity biomarkers compared to placebo (ClinicalTrials.gov NCT01996423).<\/jats:p>\n                  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Infectious Diseases and Immunology, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-9201","authenticated-orcid":false,"given":"Lorena","family":"Cifuentes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"UC Evidence Center, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8414-4452","authenticated-orcid":false,"given":"Sergio","family":"Silva\u2010Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago 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