{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:12:10Z","timestamp":1783357930029,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prurigo nodularis (PN) also known as chronic prurigo, is a chronic inflammatory skin disease characterized by intensely itchy nodules\/lesions which occur due to intensive scratching. PN management is, in part, based on clinician evaluations of PN lesions, which can be supported by clinician\u2010reported outcomes (ClinRO) such as the Prurigo Activity and Severity (PAS) instrument. A 5\u2010item version of PAS was included in recent phase\u20103 dupilumab PN trials (PRIME [NCT04183335]\/PRIME2 [NCT04202679]). The PAS score was derived using the unweighted sum of 3\u2010items of the 5\u2010item PAS (range, 0\u201311; higher score indicates worse activity and severity): Item 2 (number of lesions), Item 5a (percentage of lesions with excoriations\/crusts) and Item 5b (percentage of healed lesions) for use in clinical practice and for communication of treatment benefit to physicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the measurement properties of PAS score and derive within\u2010patient (responder definition) and between\u2010group improvement thresholds for interpreting changes in PAS score in patients with PN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data source was the pooled treatment group, intention\u2010to\u2010treat (ITT) data from the phase\u20103 PRIME (NCT04183335) and PRIME2 (NCT04202679) studies evaluating the efficacy of dupilumab in adult patients with PN with \u226520 nodules and severe itch uncontrolled with topical therapies. PAS score reliability, validity and sensitivity to change were evaluated, and anchor\u2010 and distribution\u2010based methods were applied to derive meaningful change thresholds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pooled ITT population included 311 patients (mean age 49.5\u2009years, 65.3% female). Adequate to good psychometric properties were demonstrated for PAS score. The within\u2010patient meaningful improvement threshold was estimated as 3.0 points (absolute change) and 37% (per cent change). A 1.7\u2010point (absolute change) and 20% (per cent change) improvement were estimated to reflect a between\u2010group meaningful change in PAS score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PAS score is a simple, clinically relevant indicator of PN lesion activity and severity supported by suitable psychometric performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.19961","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T07:59:55Z","timestamp":1712044795000},"page":"1954-1964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Validation of a scoring algorithm for the clinician\u2010reported outcome tool \u2018prurigo activity and severity (<scp>PAS<\/scp>)\u2019 based on clinical studies of dupilumab in adults with prurigo Nodularis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-8627","authenticated-orcid":false,"given":"Claudia","family":"Zeidler","sequence":"first","affiliation":[{"name":"Center for Chronic Pruritus University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-7786","authenticated-orcid":false,"given":"Sonja","family":"Stander","sequence":"additional","affiliation":[{"name":"Center for Chronic Pruritus University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Rhoten","sequence":"additional","affiliation":[{"name":"IQVIA  San Francisco USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Wratten","sequence":"additional","affiliation":[{"name":"IQVIA  Manchester 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.01.052"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"ZeidlerC TsianakasA PereiraM St\u00e4nderH YosipovitchG St\u00e4nderS.Chronic prurigo of nodular type: A review.2018.","DOI":"10.2340\/00015555-2774"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15107"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.649332"},{"issue":"4","key":"e_1_2_11_6_1","article-title":"Diagnostic workup and evaluation of patients with prurigo Nodularis","volume":"6","author":"Kwon CD","year":"2019","journal-title":"Medicine"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15040"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","unstructured":"ZeidlerC YosipovitchG St\u00e4nderS.Prurigo 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