{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:28:25Z","timestamp":1792024105566,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary cutaneous lymphomas are neoplasms of the immune system with a distinct tropism for the skin and an absence of extracutaneous manifestations at the time of diagnosis. Studies focusing on cutaneous lymphomas in children and adolescents remain scarce and often do not encompass the rare subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To address this knowledge gap by describing the clinical, histological and molecular characteristics of a large group of paediatric patients affected by primary cutaneous lymphoma. We also provided the <jats:italic>Paediatric Primary Cutaneous Lymphoma Atlas<\/jats:italic> that illustrates the clinicopathological spectrum of observed presentations, in the hope of supporting other physicians in the diagnostic process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review of paediatric patients diagnosed with primary cutaneous lymphomas between 1980 and 2022 at the Paediatric Dermatology Unit of Fondazione IRCCS Ca\u2032 Granda Ospedale Maggiore Policlinico, Milan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 101 patients (58 males, 43 females) met the inclusion criteria. The most common subtypes were lymphomatoid papulosis (<jats:italic>n<\/jats:italic>\u2009=\u200948) and mycosis fungoides (<jats:italic>n<\/jats:italic>\u2009=\u200931). These were followed by primary cutaneous CD4<jats:sup>+<\/jats:sup> small\/medium T\u2010cell lymphoproliferative disorders (<jats:italic>n<\/jats:italic>\u2009=\u20097), primary cutaneous anaplastic large\u2010cell lymphomas (<jats:italic>n<\/jats:italic>\u2009=\u20095), primary cutaneous marginal zone B\u2010cell lymphomas (<jats:italic>n<\/jats:italic>\u2009=\u20093), primary cutaneous follicle centre lymphomas (<jats:italic>n<\/jats:italic>\u2009=\u20092), subcutaneous panniculitis\u2010like T\u2010cell lymphomas (<jats:italic>n<\/jats:italic>\u2009=\u20092), primary cutaneous peripheral T\u2010cell lymphoma not otherwise specified (<jats:italic>n<\/jats:italic>\u2009=\u20091), primary cutaneous precursor B\u2010lymphoblastic lymphoma (<jats:italic>n<\/jats:italic>\u2009=\u20091) and S\u00e9zary syndrome (<jats:italic>n<\/jats:italic>\u2009=\u20091). Clinical follow\u2010up data covering a median of 70.8\u2009months (range 1\u2013324) were available for 74 patients, of whom three died due to cutaneous lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings shed light on the peculiar aspects and long\u2010term outcomes of paediatric cutaneous lymphomas, particularly emphasizing their distinctive features in comparison to their adult counterparts and exploring the less common subtypes. Further larger\u2010scale studies are warranted to better characterize these entities and to achieve a more rapid and accurate diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20028","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T07:24:19Z","timestamp":1713857059000},"page":"161-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Paediatric cutaneous lymphomas including rare subtypes: A 40\u2010year experience at a tertiary referral centre"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-1035","authenticated-orcid":false,"given":"Silvia","family":"Alberti\u2010Violetti","sequence":"first","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan 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Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cambiaghi","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Unit, Department of Clinical Sciences and Community Health Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-4169","authenticated-orcid":false,"given":"Angelo V.","family":"Marzano","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Berti","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Inter\u2010Hospital Pathology Division 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