{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:26:42Z","timestamp":1781360802927,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The survival benefit of sentinel lymph node biopsy (SLNB) in immunocompetent and immunosuppressed patients with high\u2010risk cutaneous squamous cell carcinoma (cSCC) has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether SLNB improves disease\u2010specific survival (DSS) in high\u2010risk cSCC. Secondary objectives were to analyse disease\u2010free survival, nodal recurrence\u2010free survival and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre, retrospective, observational cohort study comparing survival outcomes in immunosuppressed and immunocompetent patients treated with SLNB or watchful waiting. Inverse probability of treatment weighting was used to adjust for possible confounding effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 638 tumours in immunocompetent patients (SLNB <jats:italic>n<\/jats:italic>\u2009=\u200942, observation <jats:italic>n<\/jats:italic>\u2009=\u2009596) and 173 tumours in immunosuppressed patients (SLNB <jats:italic>n<\/jats:italic>\u2009=\u200928, observation <jats:italic>n<\/jats:italic>\u2009=\u2009145). Overall, SLNB was positive in 15.7% of tumours. SLNB was associated with a reduced risk of nodal recurrence (NR)\u00a0(hazard ratio [HR], 0.05 [95% CI, 0.01\u20130.43]; <jats:italic>p\u2009=<\/jats:italic>\u20090.006), disease specific mortality (HR, 0.17 [95% CI, 0.04\u20130.72]; <jats:italic>p\u2009=<\/jats:italic>\u20090.016) and all\u2010cause mortality (HR, 0.33 [95% CI, 0.15\u20130.71]; <jats:italic>p\u2009=<\/jats:italic>\u20090.004) only in immunocompetent patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SLNB was associated with improvements in NR, DSS and OS in immunocompetent but not in immunosuppressed patients with high\u2010risk cSCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20051","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:04:40Z","timestamp":1715598280000},"page":"1588-1598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sentinel lymph node biopsy versus observation in high\u2010risk cutaneous squamous cell carcinoma in immunosuppressed and immunocompetent patients: An inverse probability of treatment weighting study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-0744","authenticated-orcid":false,"given":"Antonio","family":"Tejera\u2010Vaquerizo","sequence":"first","affiliation":[{"name":"Cutaneous Oncology Unit Hospital San Juan de Dios  C\u00f3rdoba Spain"},{"name":"Dermatology Department Instituto Dermatol\u00f3gico GlobalDerm  Palma del R\u00edo C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-5623","authenticated-orcid":false,"given":"\u00c1lvaro","family":"G\u00f3mez\u2010Tom\u00e1s","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitari Vall d'Hebron  Barcelona Spain"},{"name":"Facultat de Medicina Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-1159","authenticated-orcid":false,"given":"Ane","family":"Jaka","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitari Germans Trials i Pujol, Institut d'Investigaci\u00f3 GermansTrias i Pujol, Universitat Aut\u00f2noma de Barcelona  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-0076","authenticated-orcid":false,"given":"Agust\u00edn","family":"Toll","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Cl\u00ednic de Barcelona, Universidad de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1791-2028","authenticated-orcid":false,"given":"Mar\u00eda","family":"del R\u00edo","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department Hospital Universitari Germans Trials i Pujol, Institut d'Investigaci\u00f3 GermansTrias i Pujol, Universitat Aut\u00f2noma de Barcelona  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-9596","authenticated-orcid":false,"given":"Carla","family":"Ferr\u00e1ndiz\u2010Pulido","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitari Vall d'Hebron  Barcelona Spain"},{"name":"Facultat de Medicina Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Fuente","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitari Germans Trials i Pujol, Institut d'Investigaci\u00f3 GermansTrias i Pujol, Universitat Aut\u00f2noma de Barcelona  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department Hospital Universitari Germans Trials i Pujol, Institut d'Investigaci\u00f3 GermansTrias i Pujol, Universitat Aut\u00f2noma de Barcelona  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-1885","authenticated-orcid":false,"given":"Francisco M.","family":"Almaz\u00e1n\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario Clinico San Cecilio (PTS)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-260X","authenticated-orcid":false,"given":"Tom\u00e1s","family":"Toledo\u2010Pastrana","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Quir\u00f3n Salud Infanta Luisa Hospital Quir\u00f3n Salud Sagrado Coraz\u00f3n  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-9556","authenticated-orcid":false,"given":"Ada","family":"Ferrer\u2010Fuertes","sequence":"additional","affiliation":[{"name":"Maxillofacial Department Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-1406","authenticated-orcid":false,"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Medical Sciences Department University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-2370","authenticated-orcid":false,"given":"Gianluca","family":"Avallone","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Medical Sciences Department University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-7353","authenticated-orcid":false,"given":"Javier","family":"Ca\u00f1ueto","sequence":"additional","affiliation":[{"name":"Dermatology Department Complejo Asistencial Universitario de Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-3522","authenticated-orcid":false,"given":"Jorge","family":"Santos\u2010Juanes","sequence":"additional","affiliation":[{"name":"Dermatology Department, Central Universitary Hospital of Asturias and Instituto de Investigaci\u00f3n Sanitaria of Principado de Asturias, IUOPA Oviedo University  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5611-2560","authenticated-orcid":false,"given":"Onofre","family":"Sanmart\u00edn","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2016.02.015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(08)70178\u20105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.01.035"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463\u2010021\u201000529\u20107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.3751"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15396"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818808511"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0018"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.01.008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2020.09.008"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/cer\u20102020\u20100013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280213519716"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201012\u201070"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2174"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8206"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19\u20103286"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.07.005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(197702)39:2<456::aid\u2010cncr2820390214>3.0.co;2\u2010i"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23155"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.13577"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010020\u201002082\u20101"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2021.08.041"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003085"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003304"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102901"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30601"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2022.08.050"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.02.004"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(06)70975\u20105"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33773"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010782"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.05.016"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.09.015"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26767"}],"updated-by":[{"DOI":"10.1111\/jdv.70509","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000}}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.20051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T09:10:12Z","timestamp":1732871412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.20051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,13]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/jdv.20051"],"URL":"https:\/\/doi.org\/10.1111\/jdv.20051","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,13]]},"assertion":[{"value":"2023-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}