{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:56:11Z","timestamp":1788216971999,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:00:00Z","timestamp":1716076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007543","name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9","doi-asserted-by":"publisher","award":["2021S011"],"award-info":[{"award-number":["2021S011"]}],"id":[{"id":"10.13039\/501100007543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the French pregnancy prevention program (PPP), a considerable number of pregnancies are potentially exposed to oral isotretinoin. New measures were taken by the French Medicines Agency, including the restriction of initial isotretinoin prescriptions to dermatology specialists in May 2015 and a new information campaign on teratogenicity in January 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aims were to: describe, between 2014 and 2021, compliance with PPP recommendations: isotretinoin use as a second\u2010line treatment, first prescription by a dermatology specialist, monthly prescription renewal and pregnancy testing (PT); assess the effect of the 2015 and 2019 measures on PT compliance; and identify the determinants of PT noncompliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted among women aged 11\u201350\u2009years initiating isotretinoin between 2014 and 2021 using the French Health Data System. PT compliance corresponded to pregnancy test completion and specific delays between prescription and dispensation. Time series analyses were performed to evaluate the effect of the 2015 and 2019 measures on PT compliance, and log\u2010binomial and Poisson multivariate regression models were used to identify the determinants of PT noncompliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Isotretinoin was prescribed as a second\u2010line treatment in 64% of initiations, mainly by dermatology specialists (92%). A new monthly prescription was observed in 98% of dispensations. PT compliance reached 61%, 72% and 25% at initiation, renewals and end of treatment, respectively. The 2015 measure was associated with better PT compliance at initiation and renewals. The 2019 measure had no significant effect on PT compliance at the initiation or end of treatment but was associated with a decrease in PT compliance at renewals. Age, low socioeconomic level, initiation by a nondermatology specialist and during summer were associated with PT noncompliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Understanding factors associated with PT noncompliance could help to target specific subpopulations of women treated with isotretinoin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20073","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:33:35Z","timestamp":1716186815000},"page":"806-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Compliance with the pregnancy prevention program among women initiating isotretinoin treatment between 2014 and 2021: A\u00a0nationwide cohort study on the French Health Data System (<scp>SNDS<\/scp>)"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-2064","authenticated-orcid":false,"given":"A.","family":"Havet","sequence":"first","affiliation":[{"name":"Research on Healthcare Performance (RESHAPE), INSERM U1290 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"Hospices Civils de Lyon Service Des Donn\u00e9es de Sant\u00e9  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3825-5284","authenticated-orcid":false,"given":"C.","family":"Bouvard","sequence":"additional","affiliation":[{"name":"Research on Healthcare Performance (RESHAPE), INSERM U1290 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4127-4334","authenticated-orcid":false,"given":"A.","family":"Moskal","sequence":"additional","affiliation":[{"name":"Research on Healthcare Performance (RESHAPE), INSERM U1290 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chaneli\u00e8re","sequence":"additional","affiliation":[{"name":"Research on Healthcare Performance (RESHAPE), INSERM U1290 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"Coll\u00e8ge Universitaire de M\u00e9decine G\u00e9n\u00e9rale Universit\u00e9 Lyon 1  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Massardier","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique Hospices Civils de Lyon, H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-5063","authenticated-orcid":false,"given":"B.","family":"Lebrun\u2010Vignes","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie, Centre R\u00e9gional de Pharmacovigilance, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, AP\u2010HP GH Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-3360","authenticated-orcid":false,"given":"A.\u2010P.","family":"Jonville\u2010Bera","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance, CHRU de Tours H\u00f4pital Bretonneau  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Payet","sequence":"additional","affiliation":[{"name":"Research on Healthcare Performance (RESHAPE), INSERM U1290 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"Hospices Civils de Lyon Service Des Donn\u00e9es de Sant\u00e9  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3281-1970","authenticated-orcid":false,"given":"M.","family":"Viprey","sequence":"additional","affiliation":[{"name":"Research on Healthcare Performance (RESHAPE), INSERM U1290 Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"Hospices Civils de Lyon Service Des Donn\u00e9es de Sant\u00e9  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16430"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9966"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01671.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2016.1213629"},{"key":"e_1_2_12_6_1","unstructured":"ANSM.Restriction de la prescription initiale de l'isotr\u00e9tino\u00efne orale aux dermatologues. 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